Prevention of cholesterol gallstone formation by lactobacillus acidophilus ATCC 43121 and lactobacillus fermentum MF27 in lithogenic diet-induced mice

Ju Kyoung Oh, You Ra Kim, Boin Lee, Young Min Choi, Sae Hun Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to evaluate the effects of Lactobacillus acidophilus ATCC 43121 and L. fermentum MF27 on biochemical indices in the serum, cholesterol metabolism in the liver and mucin expression in the gallbladder in lithogenic diet (LD)-induced C57BL/6J mice to determine the preventive effects of lactobacilli on gallstone formation. By the end of 4 wk of the experimental period, mice fed on a LD with high-fat and high-cholesterol exhibited higher levels of total and low-density lipoprotein cholesterol in the serum compared to mice fed on control diet or LD with L. acidophilus ATCC 43121 (LD+P1; p<0.05). Cholesterol-lowering effects observed in the LD+P1 and LD with L. fermentum MF27 (LD+P2) groups were associated with reduced expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver compared to the LD group (p<0.05). Furthermore, expression of the gel-forming mucin, including MUC5AB and MUC5B, was suppressed in the LD+P1 and LD+P2 groups compared to the LD group (p<0.05). Therefore, steady intake of both L. acidophilus ATCC 43121 and L. fermentum MF27 may have the ability to prevent the formation of cholesterol gallstones in LD-induced C57BL/6J mice.

Original languageEnglish
Pages (from-to)343-352
Number of pages10
JournalFood Science of Animal Resources
Volume41
Issue number2
DOIs
Publication statusPublished - 2021 Mar

Keywords

  • Cholesterol gallstone
  • Lactobacillus acidophilus
  • Lactobacillus fermentum
  • Lithogenic diet
  • Mucin

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology

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