Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression

Seul Ki Kim, Da Ae Kwon, Hak Sung Lee, Hyun Kyu Kim, Won-Ki Kim

Research output: Contribution to journalArticle

Abstract

We determined the functional effect of the herbal preparation, HemoHIM, on the immune system, by examining the immunomodulatory activities of HemoHIM using immunocompromised mice. In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model. Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days. The HemoHIM prevented the cisplatin-induced loss of body and organ weight. In terms of innate immunity, natural killer (NK) cell activity and phagocytosis increased in the HemoHIM group compared to the cisplatin control group. The HemoHIM group also showed a significantly higher expression of Th1-mediated cytokines (interferon gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α)) and inhibited the production of Th2-mediated cytokine interleukin-4 (IL-4) compared to cisplatin control group. These findings indicate that HemoHIM enhances immune activity by modulating immune cell activity and cytokine secretion in immune-suppressed mice.

Original languageEnglish
Article number3494806
JournalEvidence-based Complementary and Alternative Medicine
Volume2019
DOIs
Publication statusPublished - 2019 Jan 1

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Plant Preparations
Cisplatin
Cytokines
Immune System
Cytophagocytosis
Control Groups
Organ Size
Immunosuppressive Agents
HemoHIM
Innate Immunity
Natural Killer Cells
Interleukin-4
Immunosuppression
Interferon-gamma
Interleukin-2
Tumor Necrosis Factor-alpha
Body Weight

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression. / Kim, Seul Ki; Kwon, Da Ae; Lee, Hak Sung; Kim, Hyun Kyu; Kim, Won-Ki.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2019, 3494806, 01.01.2019.

Research output: Contribution to journalArticle

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