Prevertebrate local gene duplication facilitated expansion of the neuropeptide GPCR superfamily

Seongsik Yun, Michael Furlong, Mikang Sim, Minah Cho, Sumi Park, Eun Bee Cho, Arfaxad Reyes-Alcaraz, Jong-Ik Hwang, Jaebum Kim, Jae Young Seong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In humans, numerous genes encode neuropeptides that comprise a superfamily of more than 70 genes in approximately 30 families and act mainly through rhodopsin-like G protein-coupled receptors (GPCRs). Two rounds of whole-genome duplication (2R WGD) during early vertebrate evolution greatly contributed to proliferation within gene families; however, the mechanisms underlying the initial emergence and diversification of these gene families before 2R WGD are largely unknown. In this study, we analyzed 25 vertebrate rhodopsin-like neuropeptide GPCR families and their cognate peptides using phylogeny, synteny, and localization of these genes on reconstructed vertebrate ancestral chromosomes (VACs). Based on phylogeny, these GPCR families can be divided into five distinct clades, and members of each clade tend to be located on the same VACs. Similarly, their neuropeptide gene families also tend to reside on distinct VACs. Comparison of these GPCR genes with those of invertebrates including Drosophila melanogaster, Caenorhabditis elegans, Branchiostoma floridae, and Ciona intestinalis indicates that these GPCR families emerged through tandem local duplication during metazoan evolution prior to 2R WGD. Our study describes a presumptive evolutionary mechanism and development pathway of the vertebrate rhodopsin-like GPCR and cognate neuropeptide families from the urbilaterian ancestor to modern vertebrates.

Original languageEnglish
Pages (from-to)2803-2817
Number of pages15
JournalMolecular Biology and Evolution
Volume32
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

Fingerprint

Gene Duplication
gene duplication
G-Protein-Coupled Receptors
Neuropeptides
Vertebrates
vertebrates
vertebrate
protein
gene
rhodopsin
Rhodopsin
neuropeptides
Genes
genes
Chromosomes
chromosome
Phylogeny
chromosomes
Lancelets
Ciona intestinalis

Keywords

  • coevolution
  • evolutionary history
  • gene duplication
  • GPCR
  • neuropeptide
  • whole-genome duplication

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Prevertebrate local gene duplication facilitated expansion of the neuropeptide GPCR superfamily. / Yun, Seongsik; Furlong, Michael; Sim, Mikang; Cho, Minah; Park, Sumi; Cho, Eun Bee; Reyes-Alcaraz, Arfaxad; Hwang, Jong-Ik; Kim, Jaebum; Seong, Jae Young.

In: Molecular Biology and Evolution, Vol. 32, No. 11, 01.11.2015, p. 2803-2817.

Research output: Contribution to journalArticle

Yun, Seongsik ; Furlong, Michael ; Sim, Mikang ; Cho, Minah ; Park, Sumi ; Cho, Eun Bee ; Reyes-Alcaraz, Arfaxad ; Hwang, Jong-Ik ; Kim, Jaebum ; Seong, Jae Young. / Prevertebrate local gene duplication facilitated expansion of the neuropeptide GPCR superfamily. In: Molecular Biology and Evolution. 2015 ; Vol. 32, No. 11. pp. 2803-2817.
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