Primary breast lymphoma

A single institution's experience

Seung Pil Jung, Minkuk Kim, Kang Min Han, Jung Han Kim, Jee Soo Kim, Seok Jin Nam, Jeoung Won Bae, Jeong Eon Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Primary breast lymphoma is a very rare disease, accounting for 0.4-0.5% of all breast malignancies. Due to the rarity, there are only limited reports of this disease in Korean women. In this reason, we report the experience of a single institution in Korea with primary breast lymphoma (PBL). Methods: We retrospectively reviewed the medical records of 9 patients with PBL and evaluated the clinicopathologic characteristics and treatment outcomes. Results: All nine patients were female and had diffuse large B-cell lymphoma (DLBL). The median age at diagnosis was 47.9 years and the median tumor size was 3.8 cm in diameter. The most common symptom was a painless palpable mass. Five patients were classified as stage IEA and four patients were IIEA according to the Ann Arbor staging system. Four patients underwent excisional biopsy and one patient underwent a lumpectomy with sentinel lymph node biopsy due to uncertain histology of the preoperative core needle biopsy. Nine patients received anthracycline containing combined chemotherapy; among them, five patients were treated with a rituximab containing regimen. Four patients received radiotherapy combined with chemotherapy. A complete response was achieved in eight patients. During the 44 months of the median follow-up period, three cases of relapse occurred, and among them, two patients died due to disease progression. Conclusion: Most PBLs are B-cell origin, with DLBL being the most common histologic type. A combined treatment modality has been known to have positive effects on prognosis, and surgery should be limited to a diagnostic purpose.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalJournal of the Korean Surgical Society
Volume84
Issue number5
DOIs
Publication statusPublished - 2013 May 1

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Lymphoma
Breast
Lymphoma, Large B-Cell, Diffuse
Large-Core Needle Biopsy
Drug Therapy
Sentinel Lymph Node Biopsy
Segmental Mastectomy
Anthracyclines
Korea
Rare Diseases
Medical Records
Disease Progression
Neoplasms
Histology
B-Lymphocytes
Radiotherapy
Biopsy
Recurrence

Keywords

  • Breast
  • Combined modality therapy
  • Diffuse large B-cell lymphoma
  • Treatment outcome

ASJC Scopus subject areas

  • Surgery

Cite this

Jung, S. P., Kim, M., Han, K. M., Kim, J. H., Kim, J. S., Nam, S. J., ... Lee, J. E. (2013). Primary breast lymphoma: A single institution's experience. Journal of the Korean Surgical Society, 84(5), 267-272. https://doi.org/10.4174/jkss.2013.84.5.267

Primary breast lymphoma : A single institution's experience. / Jung, Seung Pil; Kim, Minkuk; Han, Kang Min; Kim, Jung Han; Kim, Jee Soo; Nam, Seok Jin; Bae, Jeoung Won; Lee, Jeong Eon.

In: Journal of the Korean Surgical Society, Vol. 84, No. 5, 01.05.2013, p. 267-272.

Research output: Contribution to journalArticle

Jung, SP, Kim, M, Han, KM, Kim, JH, Kim, JS, Nam, SJ, Bae, JW & Lee, JE 2013, 'Primary breast lymphoma: A single institution's experience', Journal of the Korean Surgical Society, vol. 84, no. 5, pp. 267-272. https://doi.org/10.4174/jkss.2013.84.5.267
Jung, Seung Pil ; Kim, Minkuk ; Han, Kang Min ; Kim, Jung Han ; Kim, Jee Soo ; Nam, Seok Jin ; Bae, Jeoung Won ; Lee, Jeong Eon. / Primary breast lymphoma : A single institution's experience. In: Journal of the Korean Surgical Society. 2013 ; Vol. 84, No. 5. pp. 267-272.
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