Primary cilia negatively regulate melanogenesis in melanocytes and pigmentation in a human skin model

Hyunjung Choi, Ji Hyun Shin, Eun Sung Kim, So Jung Park, Il Hong Bae, Yoon Kyung Jo, In Young Jeong, Hyoung June Kim, Youngjin Lee, Hea Chul Park, Hong Bae Jeon, Ki Woo Kim, Tae Ryong Lee, Dong Hyung Cho

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The primary cilium is an organelle protruding from the cell body that senses external stimuli including chemical, mechanical, light, osmotic, fluid flow, and gravitational signals. Skin is always exposed to the external environment and responds to external stimuli. Therefore, it is possible that primary cilia have an important role in skin. Ciliogenesis was reported to be involved in developmental processes in skin, such as keratinocyte differentiation and hair formation. However, the relation between skin pigmentation and primary cilia is largely unknown. Here, we observed that increased melanogenesis in melanocytes treated with a melanogenic inducer was inhibited by a ciliogenesis inducer, cytochalasin D, and serumfree culture. However, these inhibitory effects disappeared in GLI2 knockdown cells. In addition, activation of sonic hedgehog (SHH)-smoothened (Smo) signaling pathway by a Smo agonist, SAG inhibited melanin synthesis in melanocytes and pigmentation in a human skin model. On the contrary, an inhibitor of primary cilium formation, ciliobrevin A1, activated melanogenesis in melanocytes. These results suggest that skin pigmentation may be regulated partly by the induction of ciliogenesis through Smo-GLI2 signaling.

Original languageEnglish
Article numbere0168025
JournalPloS one
Issue number12
Publication statusPublished - 2016 Dec

ASJC Scopus subject areas

  • General


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