TY - JOUR
T1 - Primary hepatic marginal zone B cell lymphoma
T2 - A case report and review of the literature
AU - Yu, Young Dong
AU - Kim, Dong Sik
AU - Byun, Geon Young
AU - Lee, Jeong Hyeon
AU - Kim, In Sun
AU - Kim, Chung Yun
AU - Kim, Young Chul
AU - Suh, Sung Ock
PY - 2013/10
Y1 - 2013/10
N2 - Background Primary hepatic lymphoma (PHL) is a very rare malignancy, and constitutes about 0.016% of all cases of non-Hodgkin's lymphoma and is often misdiagnosed. The optimal therapy is still unclear and the outcomes are uncertain. Among PHLs, a primary hepatic low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is extremely rare. Methods We present a case of primary hepatic lymphoma (MALT lymphoma) treated with surgical resection and adjuvant chemotherapy. A 38-year-old Korean man, who was diagnosed with chronic hepatitis B 20 years ago, was admitted for liver biopsy after liver lesions were detected on follow-up computed tomography scan (CT). Liver biopsy revealed the diagnosis of marginal zone B-cell malignant lymphoma (MALT lymphoma). The preoperative clinical staging was IE, given that no additional foci of lymphoma were found anywhere else in the body. The patient underwent left hemihepatectomy. Subsequently, the patient received two cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) regimen. Results After 15 months of follow-up, the patient is alive and well without any evidence of disease recurrence. Conclusion Although the prognosis is variable, good response to early surgery combined with postoperative chemotherapy can be achieved in strictly selected patients.
AB - Background Primary hepatic lymphoma (PHL) is a very rare malignancy, and constitutes about 0.016% of all cases of non-Hodgkin's lymphoma and is often misdiagnosed. The optimal therapy is still unclear and the outcomes are uncertain. Among PHLs, a primary hepatic low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is extremely rare. Methods We present a case of primary hepatic lymphoma (MALT lymphoma) treated with surgical resection and adjuvant chemotherapy. A 38-year-old Korean man, who was diagnosed with chronic hepatitis B 20 years ago, was admitted for liver biopsy after liver lesions were detected on follow-up computed tomography scan (CT). Liver biopsy revealed the diagnosis of marginal zone B-cell malignant lymphoma (MALT lymphoma). The preoperative clinical staging was IE, given that no additional foci of lymphoma were found anywhere else in the body. The patient underwent left hemihepatectomy. Subsequently, the patient received two cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) regimen. Results After 15 months of follow-up, the patient is alive and well without any evidence of disease recurrence. Conclusion Although the prognosis is variable, good response to early surgery combined with postoperative chemotherapy can be achieved in strictly selected patients.
KW - Adjuvant chemotherapy
KW - Chronic hepatitis B
KW - MALT lymphoma
KW - Primary hepatic lymphoma
KW - Surgery
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U2 - 10.1007/s12262-012-0695-1
DO - 10.1007/s12262-012-0695-1
M3 - Article
AN - SCOPUS:84893476019
VL - 75
SP - 331
EP - 336
JO - Indian Journal of Surgery
JF - Indian Journal of Surgery
SN - 0972-2068
IS - 1 SUPPL.
ER -