Primary malignant mesothelioma developed in liver

Dong Sik Kim, Sung Gyu Lee, Sun Young Jun, Won Kim Kyoung, Tae Yong Ha, Keon Kuk Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The following reports a rare case of primary localized malignant mesothelioma of the liver. A 53-year-old man with no history of exposure to asbestos was admitted to our department for evaluation of incidentally detected liver mass. Computed tomography and hepatic angiogram showed a tumor at the dome of the liver, which was fed mainly through the inferior phrenic artery. The mass was resected, including a portion of the diaphragm. Microscopically, the tumor was composed of cord-like or trabecular arrangements of epithelioid cells having abundant eosinophilic cytoplasm and prominent nucleoli. Immunohistochemically, the tumor cells were strongly positive for calretinin and cytokeratin 5 and negative for hepatocyte markers. These findings were consistent with our diagnosis of epithelioid mesothelioma. A local recurrence was noted 15 months after surgery, which was treated by radiofrequency ablation. At 23 months after initial surgery, locally recurrent masses with direct invasion of the diaphragm and a solitary intrahepatic metastasis were noted, which was treated by partial excision of the diaphragm with intraoperative RFA after transarterial chemoembolization.

Original languageEnglish
Pages (from-to)1081-1084
Number of pages4
Issue number84
Publication statusPublished - 2008 May
Externally publishedYes


  • Hepatic tumor
  • Malignant mesothelioma
  • Mesothelioma

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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