Abstract
Among the 665 patients who registered at our hospital, we reviewed 39 cases of high grade primary osteosarcoma in patients who were older than 40 yr of age. The aim of this study was to determine if a primary osteosarcoma in older patients has different clinical features, and a poorer prognosis than in younger patients. Two evaluations were performed. In the first, an attempt was made to determine the possible prognostic factors such as gender, location, size, alkaline phosphatase, radiological findings, chemotherapy intensity, chemotherapy-induced tumor necrosis, and surgical margin. The second evaluation involved assessment of whether there were any significant clinical differences between older patients and adolescents. According to the results, a primary osteosarcoma in older patients did not reveal any significant prognostic variables. A primary osteosarcoma in older patients showed a poorer prognosis due to relatively unusual locations, common abnormal radiological findings, and a poor response to chemotherapy. Therefore, careful attention should be paid to making an accurate diagnosis and new strategies for more effective treatment, including chemotherapy, must to be developed in order to achieve long term survival in older patients with osteosarcoma.
| Original language | English |
|---|---|
| Pages (from-to) | 715-718 |
| Number of pages | 4 |
| Journal | Journal of Korean Medical Science |
| Volume | 21 |
| Issue number | 4 |
| Publication status | Published - 2006 Aug 15 |
| Externally published | Yes |
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Keywords
- Aged
- Osteosarcoma
- Prognosis
- Prognostic Factor
ASJC Scopus subject areas
- Medicine(all)
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Primary osteosarcoma in patients older than 40 years of age. / Dae, Geun Jeon; Soo, Yong Lee; Wan, Hyung Cho; Won, Seok Song; Park, Jong Hoon.
In: Journal of Korean Medical Science, Vol. 21, No. 4, 15.08.2006, p. 715-718.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Primary osteosarcoma in patients older than 40 years of age
AU - Dae, Geun Jeon
AU - Soo, Yong Lee
AU - Wan, Hyung Cho
AU - Won, Seok Song
AU - Park, Jong Hoon
PY - 2006/8/15
Y1 - 2006/8/15
N2 - Among the 665 patients who registered at our hospital, we reviewed 39 cases of high grade primary osteosarcoma in patients who were older than 40 yr of age. The aim of this study was to determine if a primary osteosarcoma in older patients has different clinical features, and a poorer prognosis than in younger patients. Two evaluations were performed. In the first, an attempt was made to determine the possible prognostic factors such as gender, location, size, alkaline phosphatase, radiological findings, chemotherapy intensity, chemotherapy-induced tumor necrosis, and surgical margin. The second evaluation involved assessment of whether there were any significant clinical differences between older patients and adolescents. According to the results, a primary osteosarcoma in older patients did not reveal any significant prognostic variables. A primary osteosarcoma in older patients showed a poorer prognosis due to relatively unusual locations, common abnormal radiological findings, and a poor response to chemotherapy. Therefore, careful attention should be paid to making an accurate diagnosis and new strategies for more effective treatment, including chemotherapy, must to be developed in order to achieve long term survival in older patients with osteosarcoma.
AB - Among the 665 patients who registered at our hospital, we reviewed 39 cases of high grade primary osteosarcoma in patients who were older than 40 yr of age. The aim of this study was to determine if a primary osteosarcoma in older patients has different clinical features, and a poorer prognosis than in younger patients. Two evaluations were performed. In the first, an attempt was made to determine the possible prognostic factors such as gender, location, size, alkaline phosphatase, radiological findings, chemotherapy intensity, chemotherapy-induced tumor necrosis, and surgical margin. The second evaluation involved assessment of whether there were any significant clinical differences between older patients and adolescents. According to the results, a primary osteosarcoma in older patients did not reveal any significant prognostic variables. A primary osteosarcoma in older patients showed a poorer prognosis due to relatively unusual locations, common abnormal radiological findings, and a poor response to chemotherapy. Therefore, careful attention should be paid to making an accurate diagnosis and new strategies for more effective treatment, including chemotherapy, must to be developed in order to achieve long term survival in older patients with osteosarcoma.
KW - Aged
KW - Osteosarcoma
KW - Prognosis
KW - Prognostic Factor
UR - http://www.scopus.com/inward/record.url?scp=33746913847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746913847&partnerID=8YFLogxK
M3 - Review article
C2 - 16891818
AN - SCOPUS:33746913847
VL - 21
SP - 715
EP - 718
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 4
ER -