Primary small cell carcinoma of the endometrium: Report of a case with immunochemical studies

Jong Ha Hwang, Jae Kwan Lee, Nak Woo Lee, Kyu Wan Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

BACKGROUND: Small cell carcinoma (SCC) is a well-known tumor that occurs predominantly in the lung. These tumors may also occur in the female genital tract, where it occurs most commonly in the cervix. Primary SCC of the endometrium is extremely rare. We report a case of an endometrial tumor that was a combination of an SCC and endometrioid adenocarcinoma with squamous components and that penetrated half of the thickness of the uterine wall. CASE: A 59-year-old, postmenopausal woman suffering from postmenopausal bleeding presented for care. The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic and paraaortic lymph node dissection, followed by concurrent chemoradiotherapy. Immunohistochemical studies showed neuroendocrine differentiation with positive CD 56, chromogranin and synaptophysin markers. CONCLUSION: Immunohistochemical analyses are helpful in diagnosing and differentiating primary SCC of the endometrium from benign and malignant diseases of the endometrium.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume55
Issue number1-2
Publication statusPublished - 2010 Jan 1

Fingerprint

Small Cell Carcinoma
Endometrial Neoplasms
Chromogranins
Endometrioid Carcinoma
Neoplasms
Synaptophysin
Ovariectomy
Chemoradiotherapy
Endometrium
Lymph Node Excision
Hysterectomy
Cervix Uteri
Hemorrhage
Lung

Keywords

  • Endometrial cancer
  • Immunochemistry
  • Small cell carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Primary small cell carcinoma of the endometrium : Report of a case with immunochemical studies. / Hwang, Jong Ha; Lee, Jae Kwan; Lee, Nak Woo; Lee, Kyu Wan.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 55, No. 1-2, 01.01.2010, p. 81-86.

Research output: Contribution to journalArticle

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AB - BACKGROUND: Small cell carcinoma (SCC) is a well-known tumor that occurs predominantly in the lung. These tumors may also occur in the female genital tract, where it occurs most commonly in the cervix. Primary SCC of the endometrium is extremely rare. We report a case of an endometrial tumor that was a combination of an SCC and endometrioid adenocarcinoma with squamous components and that penetrated half of the thickness of the uterine wall. CASE: A 59-year-old, postmenopausal woman suffering from postmenopausal bleeding presented for care. The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic and paraaortic lymph node dissection, followed by concurrent chemoradiotherapy. Immunohistochemical studies showed neuroendocrine differentiation with positive CD 56, chromogranin and synaptophysin markers. CONCLUSION: Immunohistochemical analyses are helpful in diagnosing and differentiating primary SCC of the endometrium from benign and malignant diseases of the endometrium.

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