Priority setting for the management of chemicals using the globally harmonized system and multivariate analysis: Use of the mahalanobis-taguchi system

Hong Lyuer Lim, Eun Hae Huh, Da An Huh, Jong Ryeul Sohn, Kyong Whan Moon

Research output: Contribution to journalArticle

1 Citation (Scopus)


This study aims to provide a new methodology using the Globally Harmonized System (GHS) and the Mahalanobis–Taguchi System (MTS) that can be used to assess the overall hazard of a chemical using GHS information. Previously, hazardous chemicals were designated and managed by the Chemical Management Act, but many more chemicals are now in use. Damage prediction modeling programs predict the extent of damage and proactively manage high-risk chemicals, but the lack of physical and chemical characterization information relating to chemicals has limitations that cannot be modeled. To overcome such limitations, a new method of chemical management prioritization was developed using the GHS and Mahalanobis–Taguchi System (MTS). For effective management, the risk of a chemical can be ranked according to a comprehensive risk assessment and calculated through multivariate analysis using the GHS. Relative hazards are then identified using MTS multivariate analysis with GHS information, even when there is insufficient information about the chemical’s characteristics, and the method can be applied to a large number of different chemicals.

Original languageEnglish
Article number3119
JournalInternational journal of environmental research and public health
Issue number17
Publication statusPublished - 2019 Sep 1



  • Chemical ranking and scoring
  • Globally harmonized system
  • Mahalanobis
  • Priority setting
  • Taguchi system

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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