Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer

Quan Liu; Zhongjian Xie; Meng Qiu; Inseob Shim; Yunlong Yang; Sisi Xie; Qinhe Yang; Dou Wang; Shiyou Chen; Taojian Fan; Bo Ding; Ziheng Guo; Dickson Adah; Xinhuang Yao; Yuhua Zhang; Hong Wu; Zongze Wu; Chaoying Wei; Hongzhong Wang; Hyeong Seok Kim; Qingshuang Zou; Qiaoting Yan; Zhen Cai; Jong Seung Kim; Li Ping Liu; Han Zhang; Yihai Cao

doi:10.1002/advs.202001191

Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer

Quan Liu, Zhongjian Xie, Meng Qiu, Inseob Shim, Yunlong Yang, Sisi Xie, Qinhe Yang, Dou Wang, Shiyou Chen, Taojian Fan, Bo Ding, Ziheng Guo, Dickson Adah, Xinhuang Yao, Yuhua Zhang, Hong Wu, Zongze Wu, Chaoying Wei, Hongzhong Wang, Hyeong Seok KimQingshuang Zou, Qiaoting Yan, Zhen Cai, Jong Seung Kim, Li Ping Liu, Han Zhang, Yihai Cao

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.

Original language	English
Article number	2001191
Journal	Advanced Science
Volume	7
Issue number	24
DOIs	https://doi.org/10.1002/advs.202001191
Publication status	Published - 2020 Dec 16

Keywords

angiogenesis
chemotherapy
photothermal therapy
prodrug
zirconium carbide

ASJC Scopus subject areas

Medicine (miscellaneous)
Chemical Engineering(all)
Materials Science(all)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Engineering(all)
Physics and Astronomy(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/advs.202001191

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Liu, Q., Xie, Z., Qiu, M., Shim, I., Yang, Y., Xie, S., Yang, Q., Wang, D., Chen, S., Fan, T., Ding, B., Guo, Z., Adah, D., Yao, X., Zhang, Y., Wu, H., Wu, Z., Wei, C., Wang, H., ... Cao, Y. (2020). Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer. Advanced Science, 7(24), [2001191]. https://doi.org/10.1002/advs.202001191

Liu, Q, Xie, Z, Qiu, M, Shim, I, Yang, Y, Xie, S, Yang, Q, Wang, D, Chen, S, Fan, T, Ding, B, Guo, Z, Adah, D, Yao, X, Zhang, Y, Wu, H, Wu, Z, Wei, C, Wang, H, Kim, HS, Zou, Q, Yan, Q, Cai, Z, Kim, JS, Liu, LP, Zhang, H & Cao, Y 2020, 'Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer', Advanced Science, vol. 7, no. 24, 2001191. https://doi.org/10.1002/advs.202001191

@article{dd71b7fd71114d7bbfc89b8d3b99c668,

title = "Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer",

abstract = "Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.",

keywords = "angiogenesis, chemotherapy, photothermal therapy, prodrug, zirconium carbide",

author = "Quan Liu and Zhongjian Xie and Meng Qiu and Inseob Shim and Yunlong Yang and Sisi Xie and Qinhe Yang and Dou Wang and Shiyou Chen and Taojian Fan and Bo Ding and Ziheng Guo and Dickson Adah and Xinhuang Yao and Yuhua Zhang and Hong Wu and Zongze Wu and Chaoying Wei and Hongzhong Wang and Kim, {Hyeong Seok} and Qingshuang Zou and Qiaoting Yan and Zhen Cai and Kim, {Jong Seung} and Liu, {Li Ping} and Han Zhang and Yihai Cao",

note = "Funding Information: The authors acknowledge financial support from the National Natural Science Foundation of China (61435010 and 61575089, H.Z.; U1803128, M.Q.), the Science and Technology Innovation Commission of Shenzhen (KQTD2015032416270385, JCYJ20150625103619275, H.Z.; JCYJ20180305124854790, M.Q.; KQJSCX20180321164801762, L.P.L.), the China Postdoctoral Science Foundation (2017M610540, 2018T110892, M.Q.; 2018M643364, Q.L.), the Ph.D. Start‐up Fund of Natural Science Foundation of Guangdong Province, China (2018A030310040, Q.L.; 2018A030310500, M.Q.), the Ph.D. Fund of Natural Science Foundation of Shandong Province, China (ZR2016BB33, M.Q.), the CRI project (2018R1A3B1052702, J.S.K.) from the National Research Foundation of Korea, and the Taishan Scholar Project of Shandong Province (tsqn201909054, M.Q.) Publisher Copyright: {\textcopyright} 2020 The Authors. Published by Wiley-VCH GmbH",

year = "2020",

month = dec,

day = "16",

doi = "10.1002/advs.202001191",

language = "English",

volume = "7",

journal = "Advanced Science",

issn = "2198-3844",

publisher = "Wiley-VCH Verlag",

number = "24",

}

TY - JOUR

T1 - Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer

AU - Liu, Quan

AU - Xie, Zhongjian

AU - Qiu, Meng

AU - Shim, Inseob

AU - Yang, Yunlong

AU - Xie, Sisi

AU - Yang, Qinhe

AU - Wang, Dou

AU - Chen, Shiyou

AU - Fan, Taojian

AU - Ding, Bo

AU - Guo, Ziheng

AU - Adah, Dickson

AU - Yao, Xinhuang

AU - Zhang, Yuhua

AU - Wu, Hong

AU - Wu, Zongze

AU - Wei, Chaoying

AU - Wang, Hongzhong

AU - Kim, Hyeong Seok

AU - Zou, Qingshuang

AU - Yan, Qiaoting

AU - Cai, Zhen

AU - Kim, Jong Seung

AU - Liu, Li Ping

AU - Zhang, Han

AU - Cao, Yihai

N1 - Funding Information: The authors acknowledge financial support from the National Natural Science Foundation of China (61435010 and 61575089, H.Z.; U1803128, M.Q.), the Science and Technology Innovation Commission of Shenzhen (KQTD2015032416270385, JCYJ20150625103619275, H.Z.; JCYJ20180305124854790, M.Q.; KQJSCX20180321164801762, L.P.L.), the China Postdoctoral Science Foundation (2017M610540, 2018T110892, M.Q.; 2018M643364, Q.L.), the Ph.D. Start‐up Fund of Natural Science Foundation of Guangdong Province, China (2018A030310040, Q.L.; 2018A030310500, M.Q.), the Ph.D. Fund of Natural Science Foundation of Shandong Province, China (ZR2016BB33, M.Q.), the CRI project (2018R1A3B1052702, J.S.K.) from the National Research Foundation of Korea, and the Taishan Scholar Project of Shandong Province (tsqn201909054, M.Q.) Publisher Copyright: © 2020 The Authors. Published by Wiley-VCH GmbH

PY - 2020/12/16

Y1 - 2020/12/16

N2 - Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.

AB - Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation into clinical practice. Here, a promising biophotonic nanoplatform is developed based on the zirconium carbide (ZrC) nanosheet as a deep PTT-photosensitizer and on-demand designed anticancer prodrug SN38-Nif, which is released and activated by photothermia and tumor-overexpressed esterase. In vitro and in vivo experimental evidence shows the potent anticancer effects of the integrated ZrC@prodrug biophotonic nanoplatform by specifically targeting malignant cells, chemotherapy/hyperthermia-induced tumor inflammation, and angiogenesis. In mouse models, the ZrC@prodrug system markedly inhibits tumor recurrence, metastasis, inflammation and angiogenesis. The findings unravel a promising biophotonic strategy for precision treatment of cancer.

KW - angiogenesis

KW - chemotherapy

KW - photothermal therapy

KW - prodrug

KW - zirconium carbide

UR - http://www.scopus.com/inward/record.url?scp=85096802131&partnerID=8YFLogxK

U2 - 10.1002/advs.202001191

DO - 10.1002/advs.202001191

M3 - Article

AN - SCOPUS:85096802131

SN - 2198-3844

VL - 7

JO - Advanced Science

JF - Advanced Science

IS - 24

M1 - 2001191

ER -

Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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