Abstract
We produced highly aligned porous poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds by unidirectionally freezing PCL/HA solutions with various HA contents (0, 5, 10 and 20 wt% in relation to the PCL polymer) and evaluated their mechanical properties and in vitro biocompatibility to examine their potential applications in bone tissue engineering. All the prepared scaffolds had a highly aligned porous structure, in which the HA particles were uniformly dispersed in the PCL walls. The elastic modulus of the PCL/HA scaffolds significantly increased from 0.12 ± 0.02 to 2.65 ± 0.05 MPa with increasing initial HA content from 0 to 20 wt%, whereas the pore size decreased from 9.2 ± 0.7 to 4.2 ± 0.8 μm. In addition, the PCL/HA scaffolds showed considerably enhanced in vitro cellular responses that were assessed in terms of cell attachment, proliferation and osteoblastic differentiation.
| Original language | English |
|---|---|
| Pages (from-to) | 701-708 |
| Number of pages | 8 |
| Journal | Journal of Porous Materials |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2013 Aug 1 |
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Keywords
- Biocompatibility
- Hydroxyapatite
- Poly(ε-caprolactone) (PCL)
- Porous
- Scaffold
ASJC Scopus subject areas
- Mechanical Engineering
- Mechanics of Materials
- Materials Science(all)
Cite this
Production, mechanical properties and in vitro biocompatibility of highly aligned porous poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds. / Choi, Won Young; Kim, Hyoun Ee; Koh, Young-Hag.
In: Journal of Porous Materials, Vol. 20, No. 4, 01.08.2013, p. 701-708.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Production, mechanical properties and in vitro biocompatibility of highly aligned porous poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds
AU - Choi, Won Young
AU - Kim, Hyoun Ee
AU - Koh, Young-Hag
PY - 2013/8/1
Y1 - 2013/8/1
N2 - We produced highly aligned porous poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds by unidirectionally freezing PCL/HA solutions with various HA contents (0, 5, 10 and 20 wt% in relation to the PCL polymer) and evaluated their mechanical properties and in vitro biocompatibility to examine their potential applications in bone tissue engineering. All the prepared scaffolds had a highly aligned porous structure, in which the HA particles were uniformly dispersed in the PCL walls. The elastic modulus of the PCL/HA scaffolds significantly increased from 0.12 ± 0.02 to 2.65 ± 0.05 MPa with increasing initial HA content from 0 to 20 wt%, whereas the pore size decreased from 9.2 ± 0.7 to 4.2 ± 0.8 μm. In addition, the PCL/HA scaffolds showed considerably enhanced in vitro cellular responses that were assessed in terms of cell attachment, proliferation and osteoblastic differentiation.
AB - We produced highly aligned porous poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) scaffolds by unidirectionally freezing PCL/HA solutions with various HA contents (0, 5, 10 and 20 wt% in relation to the PCL polymer) and evaluated their mechanical properties and in vitro biocompatibility to examine their potential applications in bone tissue engineering. All the prepared scaffolds had a highly aligned porous structure, in which the HA particles were uniformly dispersed in the PCL walls. The elastic modulus of the PCL/HA scaffolds significantly increased from 0.12 ± 0.02 to 2.65 ± 0.05 MPa with increasing initial HA content from 0 to 20 wt%, whereas the pore size decreased from 9.2 ± 0.7 to 4.2 ± 0.8 μm. In addition, the PCL/HA scaffolds showed considerably enhanced in vitro cellular responses that were assessed in terms of cell attachment, proliferation and osteoblastic differentiation.
KW - Biocompatibility
KW - Hydroxyapatite
KW - Poly(ε-caprolactone) (PCL)
KW - Porous
KW - Scaffold
UR - http://www.scopus.com/inward/record.url?scp=84879882795&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879882795&partnerID=8YFLogxK
U2 - 10.1007/s10934-012-9644-4
DO - 10.1007/s10934-012-9644-4
M3 - Article
AN - SCOPUS:84879882795
VL - 20
SP - 701
EP - 708
JO - Journal of Porous Materials
JF - Journal of Porous Materials
SN - 1380-2224
IS - 4
ER -