Production of HBsAg by growth rate control with recombinant Saccharomycescerevisiae in fed-batch

Man Bock Gu, Kyung Hwan Jung, Mahn Hoon Park, Kwang Soon Shin, Kyong Ho Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To maintain a constant specific growth rate for a recombinant S. cerevisiae in fed-batch, the medium feeding rate has been controlled with respect to the hourly calculated glucose uptake rate. The recombinant yeast producing HBsAg showed the exponential production trend in proportion to the exponential cell growth. Total cell yield in fed-batch was about 0.402 g cells/g glucose, and HBsAg was produced about ten times more than in batch. Decrease of growth rate by HBsAg produced was not shown.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalBiotechnology letters
Volume11
Issue number1
DOIs
Publication statusPublished - 1989 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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