Production of highly porous triphasic calcium phosphate scaffolds with excellent in vitro bioactivity using vacuum-assisted foaming of ceramic suspension (VFC) technique

Min Kyung Ahn, Young Wook Moon, Young Hag Koh, Hyoun Ee Kim

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We produced highly porous triphasic calcium phosphate (CaP) scaffolds, comprising of hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and α-TCP phases, using vacuum-assisted foaming of a ceramic suspension (VFC) technique. In particular, vigorously foamed CaP green bodies with a composition of ∼60 wt% HA and 40 wt% β-TCP were sintered at relatively high temperatures (1200, 1250, 1300, and 1350 °C) to control the amount of three constituent phases. All the produced samples showed a highly porous structure (porosity ∼ 83.5-84.5 vol%, pore size ∼ 312-338 μm, and interconnection size ∼ 61-74 μm) with a number of microchannels in the CaP walls. However, sintering at relatively high temperatures≥1250 °C induced considerable phase transformation of the β-TCP to α-TCP phases. The presence of the more soluble α-TCP phase in the triphasic CaP scaffolds significantly enhanced the in vitro bioactivity of the porous CaP scaffolds, which was assessed in terms of their apatite-forming ability in simulated body fluid (SBF).

Original languageEnglish
Pages (from-to)5879-5885
Number of pages7
JournalCeramics International
Volume39
Issue number5
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Bioactivity
  • Foaming
  • Freezing
  • Porous calcium phosphate

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

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