TY - JOUR
T1 - Production of highly porous triphasic calcium phosphate scaffolds with excellent in vitro bioactivity using vacuum-assisted foaming of ceramic suspension (VFC) technique
AU - Ahn, Min Kyung
AU - Moon, Young Wook
AU - Koh, Young Hag
AU - Kim, Hyoun Ee
N1 - Funding Information:
This work was supported by the Korea Science and Engineering Foundation(KOSEF) grant funded by the Korea government(MEST) (No. 2012R1A1B3003128 ).
Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/7
Y1 - 2013/7
N2 - We produced highly porous triphasic calcium phosphate (CaP) scaffolds, comprising of hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and α-TCP phases, using vacuum-assisted foaming of a ceramic suspension (VFC) technique. In particular, vigorously foamed CaP green bodies with a composition of ∼60 wt% HA and 40 wt% β-TCP were sintered at relatively high temperatures (1200, 1250, 1300, and 1350 °C) to control the amount of three constituent phases. All the produced samples showed a highly porous structure (porosity ∼ 83.5-84.5 vol%, pore size ∼ 312-338 μm, and interconnection size ∼ 61-74 μm) with a number of microchannels in the CaP walls. However, sintering at relatively high temperatures≥1250 °C induced considerable phase transformation of the β-TCP to α-TCP phases. The presence of the more soluble α-TCP phase in the triphasic CaP scaffolds significantly enhanced the in vitro bioactivity of the porous CaP scaffolds, which was assessed in terms of their apatite-forming ability in simulated body fluid (SBF).
AB - We produced highly porous triphasic calcium phosphate (CaP) scaffolds, comprising of hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and α-TCP phases, using vacuum-assisted foaming of a ceramic suspension (VFC) technique. In particular, vigorously foamed CaP green bodies with a composition of ∼60 wt% HA and 40 wt% β-TCP were sintered at relatively high temperatures (1200, 1250, 1300, and 1350 °C) to control the amount of three constituent phases. All the produced samples showed a highly porous structure (porosity ∼ 83.5-84.5 vol%, pore size ∼ 312-338 μm, and interconnection size ∼ 61-74 μm) with a number of microchannels in the CaP walls. However, sintering at relatively high temperatures≥1250 °C induced considerable phase transformation of the β-TCP to α-TCP phases. The presence of the more soluble α-TCP phase in the triphasic CaP scaffolds significantly enhanced the in vitro bioactivity of the porous CaP scaffolds, which was assessed in terms of their apatite-forming ability in simulated body fluid (SBF).
KW - Bioactivity
KW - Foaming
KW - Freezing
KW - Porous calcium phosphate
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U2 - 10.1016/j.ceramint.2013.01.006
DO - 10.1016/j.ceramint.2013.01.006
M3 - Article
AN - SCOPUS:84875704483
SN - 0272-8842
VL - 39
SP - 5879
EP - 5885
JO - Ceramics International
JF - Ceramics International
IS - 5
ER -