Abstract
We produced highly porous triphasic calcium phosphate (CaP) scaffolds, comprising of hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and α-TCP phases, using vacuum-assisted foaming of a ceramic suspension (VFC) technique. In particular, vigorously foamed CaP green bodies with a composition of ∼60 wt% HA and 40 wt% β-TCP were sintered at relatively high temperatures (1200, 1250, 1300, and 1350 °C) to control the amount of three constituent phases. All the produced samples showed a highly porous structure (porosity ∼ 83.5-84.5 vol%, pore size ∼ 312-338 μm, and interconnection size ∼ 61-74 μm) with a number of microchannels in the CaP walls. However, sintering at relatively high temperatures≥1250 °C induced considerable phase transformation of the β-TCP to α-TCP phases. The presence of the more soluble α-TCP phase in the triphasic CaP scaffolds significantly enhanced the in vitro bioactivity of the porous CaP scaffolds, which was assessed in terms of their apatite-forming ability in simulated body fluid (SBF).
| Original language | English |
|---|---|
| Pages (from-to) | 5879-5885 |
| Number of pages | 7 |
| Journal | Ceramics International |
| Volume | 39 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2013 Jul 1 |
Fingerprint
Keywords
- Bioactivity
- Foaming
- Freezing
- Porous calcium phosphate
ASJC Scopus subject areas
- Ceramics and Composites
- Process Chemistry and Technology
- Electronic, Optical and Magnetic Materials
- Surfaces, Coatings and Films
- Materials Chemistry
Cite this
Production of highly porous triphasic calcium phosphate scaffolds with excellent in vitro bioactivity using vacuum-assisted foaming of ceramic suspension (VFC) technique. / Ahn, Min Kyung; Moon, Young Wook; Koh, Young-Hag; Kim, Hyoun Ee.
In: Ceramics International, Vol. 39, No. 5, 01.07.2013, p. 5879-5885.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Production of highly porous triphasic calcium phosphate scaffolds with excellent in vitro bioactivity using vacuum-assisted foaming of ceramic suspension (VFC) technique
AU - Ahn, Min Kyung
AU - Moon, Young Wook
AU - Koh, Young-Hag
AU - Kim, Hyoun Ee
PY - 2013/7/1
Y1 - 2013/7/1
N2 - We produced highly porous triphasic calcium phosphate (CaP) scaffolds, comprising of hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and α-TCP phases, using vacuum-assisted foaming of a ceramic suspension (VFC) technique. In particular, vigorously foamed CaP green bodies with a composition of ∼60 wt% HA and 40 wt% β-TCP were sintered at relatively high temperatures (1200, 1250, 1300, and 1350 °C) to control the amount of three constituent phases. All the produced samples showed a highly porous structure (porosity ∼ 83.5-84.5 vol%, pore size ∼ 312-338 μm, and interconnection size ∼ 61-74 μm) with a number of microchannels in the CaP walls. However, sintering at relatively high temperatures≥1250 °C induced considerable phase transformation of the β-TCP to α-TCP phases. The presence of the more soluble α-TCP phase in the triphasic CaP scaffolds significantly enhanced the in vitro bioactivity of the porous CaP scaffolds, which was assessed in terms of their apatite-forming ability in simulated body fluid (SBF).
AB - We produced highly porous triphasic calcium phosphate (CaP) scaffolds, comprising of hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and α-TCP phases, using vacuum-assisted foaming of a ceramic suspension (VFC) technique. In particular, vigorously foamed CaP green bodies with a composition of ∼60 wt% HA and 40 wt% β-TCP were sintered at relatively high temperatures (1200, 1250, 1300, and 1350 °C) to control the amount of three constituent phases. All the produced samples showed a highly porous structure (porosity ∼ 83.5-84.5 vol%, pore size ∼ 312-338 μm, and interconnection size ∼ 61-74 μm) with a number of microchannels in the CaP walls. However, sintering at relatively high temperatures≥1250 °C induced considerable phase transformation of the β-TCP to α-TCP phases. The presence of the more soluble α-TCP phase in the triphasic CaP scaffolds significantly enhanced the in vitro bioactivity of the porous CaP scaffolds, which was assessed in terms of their apatite-forming ability in simulated body fluid (SBF).
KW - Bioactivity
KW - Foaming
KW - Freezing
KW - Porous calcium phosphate
UR - http://www.scopus.com/inward/record.url?scp=84875704483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875704483&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2013.01.006
DO - 10.1016/j.ceramint.2013.01.006
M3 - Article
AN - SCOPUS:84875704483
VL - 39
SP - 5879
EP - 5885
JO - Ceramics International
JF - Ceramics International
SN - 0272-8842
IS - 5
ER -