Production of penicillic acid by Aspergillus sclerotiorum CGF

S. W. Kang, C. H. Park, S. I. Hong, S. W. Kim

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The production of penicillic acid by Aspergillus sclerotiorum CGF for the biocontrol of Phytophthora disease was investigated in submerged fermentation using media composed of different nutrients. Soluble starch was found to be the most effective substrate among the carbon sources used, and produced the highest penicillic acid concentration of 2.98 mg ml-1. When organic nitrogen sources were used, pharmamedia, yeast extract, and polypeptone-S were found to be suitable organic nitrogen sources (2.46-2.71 mg ml-1). The production of penicillic acid was not detected in when inorganic nitrogen sources were used. Only Na2HPO4, among the metal ions and phosphate salts tested, increased the production of penicillic acid (≈20%). When A. sclerotiorum CGF was cultured in optimal medium [8.0% (w/v) soluble starch, 0.6% (w/v) yeast extract, and 0.3% (w/v) Na2HPO4], maximum penicillic acid concentration (≈9.40 mg ml-1) and cell mass (≈17.4 g l-1) were obtained after 12 days.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalBioresource technology
Issue number1
Publication statusPublished - 2007 Jan


  • Aspergillus sclerotiorum
  • Penicillic acid
  • Phytophthora species
  • Submerged fermentation

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


Dive into the research topics of 'Production of penicillic acid by Aspergillus sclerotiorum CGF'. Together they form a unique fingerprint.

Cite this