Production of poly(ε-caprolactone)/hydroxyapatite composite scaffolds with a tailored macro/micro-porous structure, high mechanical properties, and excellent bioactivity

Jong Woo Kim, Kwan Ha Shin, Young-Hag Koh, Min Jin Hah, Jiyoung Moon, Hyoun Ee Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We produced poro-us poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite scaffolds for bone regeneration, which can have a tailored macro/micro-porous structure with high mechanical properties and excellent in vitro bioactivity using non-solvent-induced phase separation (NIPS)-based 3D plotting. This innovative 3D plotting technique can create highly microporous PCL/HA composite filaments by inducing unique phase separation in PCL/HA solutions through the non-solvent-solvent exchange phenomenon. The PCL/HA composite scaffolds produced with various HA contents (0 wt %, 10 wt %, 15 wt %, and 20 wt %) showed that PCL/HA composite struts with highly microporous structures were well constructed in a controlled periodic pattern. Similar levels of overall porosity (~78 vol %) and pore size (~248 μm) were observed for all the PCL/HA composite scaffolds, which would be highly beneficial to bone tissue regeneration. Mechanical properties, such as ultimate tensile strength and compressive yield strength, increased with an increase in HA content. In addition, incorporating bioactive HA particles into the PCL polymer led to remarkable enhancements in in vitro apatite-forming ability.

Original languageEnglish
Article number1123
JournalMaterials
Volume10
Issue number10
DOIs
Publication statusPublished - 2017 Sep 22

Fingerprint

Durapatite
Bioactivity
Hydroxyapatite
Scaffolds
Macros
Mechanical properties
Composite materials
Phase separation
Bone
polycaprolactone
Apatites
Tissue regeneration
Struts
Apatite
Pore size
Yield stress
Ion exchange
Polymers
Tensile strength
Porosity

Keywords

  • 3D plotting
  • Cytocompatibility
  • Hydroxyapatite
  • Poly(ε-caprolactone)
  • Porous scaffolds

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Production of poly(ε-caprolactone)/hydroxyapatite composite scaffolds with a tailored macro/micro-porous structure, high mechanical properties, and excellent bioactivity. / Kim, Jong Woo; Shin, Kwan Ha; Koh, Young-Hag; Hah, Min Jin; Moon, Jiyoung; Kim, Hyoun Ee.

In: Materials, Vol. 10, No. 10, 1123, 22.09.2017.

Research output: Contribution to journalArticle

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