Production of poly(ε-caprolactone)/hydroxyapatite composite scaffolds with a tailored macro/micro-porous structure, high mechanical properties, and excellent bioactivity

Jong Woo Kim, Kwan Ha Shin, Young-Hag Koh, Min Jin Hah, Jiyoung Moon, Hyoun Ee Kim

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We produced poro-us poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite scaffolds for bone regeneration, which can have a tailored macro/micro-porous structure with high mechanical properties and excellent in vitro bioactivity using non-solvent-induced phase separation (NIPS)-based 3D plotting. This innovative 3D plotting technique can create highly microporous PCL/HA composite filaments by inducing unique phase separation in PCL/HA solutions through the non-solvent-solvent exchange phenomenon. The PCL/HA composite scaffolds produced with various HA contents (0 wt %, 10 wt %, 15 wt %, and 20 wt %) showed that PCL/HA composite struts with highly microporous structures were well constructed in a controlled periodic pattern. Similar levels of overall porosity (~78 vol %) and pore size (~248 μm) were observed for all the PCL/HA composite scaffolds, which would be highly beneficial to bone tissue regeneration. Mechanical properties, such as ultimate tensile strength and compressive yield strength, increased with an increase in HA content. In addition, incorporating bioactive HA particles into the PCL polymer led to remarkable enhancements in in vitro apatite-forming ability.

Original languageEnglish
Article number1123
JournalMaterials
Volume10
Issue number10
DOIs
Publication statusPublished - 2017 Sep 22

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Keywords

  • 3D plotting
  • Cytocompatibility
  • Hydroxyapatite
  • Poly(ε-caprolactone)
  • Porous scaffolds

ASJC Scopus subject areas

  • Materials Science(all)

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