Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized, estrogen treated adult rats

Byung N. Cho, Jae Y. Seong, Hyeseong Cho, Kyungjin Kim

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatory action of P on GnRH mRNA level. These results strongly suggest that P regulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalBrain Research
Volume652
Issue number1
DOIs
Publication statusPublished - 1994 Jul 25
Externally publishedYes

Keywords

  • Gonadotropin-releasing hormone mRNA
  • Hypothalamus
  • Progesterone
  • RU486

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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