Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized, estrogen treated adult rats

Byung N. Cho; Jae Y. Seong; Hyeseong Cho; Kyungjin Kim

doi:10.1016/0006-8993(94)90336-0

Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized, estrogen treated adult rats

Byung N. Cho, Jae Y. Seong, Hyeseong Cho, Kyungjin Kim

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatory action of P on GnRH mRNA level. These results strongly suggest that P regulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Brain Research
Volume	652
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(94)90336-0
Publication status	Published - 1994 Jul 25
Externally published	Yes

Keywords

Gonadotropin-releasing hormone mRNA
Hypothalamus
Progesterone
RU486

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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