Abstract
Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatory action of P on GnRH mRNA level. These results strongly suggest that P regulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.
| Original language | English |
|---|---|
| Pages (from-to) | 177-180 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 652 |
| Issue number | 1 |
| Publication status | Published - 1994 Jul 25 |
| Externally published | Yes |
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Keywords
- Gonadotropin-releasing hormone mRNA
- Hypothalamus
- Progesterone
- RU486
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Molecular Biology
- Developmental Biology
Cite this
Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized, estrogen treated adult rats. / Cho, Byung N.; Seong, Jae Young; Cho, Hyeseong; Kim, Kyungjin.
In: Brain Research, Vol. 652, No. 1, 25.07.1994, p. 177-180.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Progesterone stimulates GnRH gene expression in the hypothalamus of ovariectomized, estrogen treated adult rats
AU - Cho, Byung N.
AU - Seong, Jae Young
AU - Cho, Hyeseong
AU - Kim, Kyungjin
PY - 1994/7/25
Y1 - 1994/7/25
N2 - Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatory action of P on GnRH mRNA level. These results strongly suggest that P regulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.
AB - Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Progesterone (P) is known to affect release and content of GnRH. The action mechanism of P on GnRH mRNA level remains, however, to be resolved. Here we report that P augments GnRH mRNA level in hypothalamic tissues derived from ovariectomized, estradiol-treated adult rats. The stimulatory action of P was time-dependent and lasted at least for 9 h. When RU486, a P receptor antagonist, was administered 1 hr before P treatment, it clearly blocked the stimulatory action of P on GnRH mRNA level. These results strongly suggest that P regulates GnRH gene expression in the rat hypothalamus, presumably through the P receptor-mediated mechanism.
KW - Gonadotropin-releasing hormone mRNA
KW - Hypothalamus
KW - Progesterone
KW - RU486
UR - http://www.scopus.com/inward/record.url?scp=0028238068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028238068&partnerID=8YFLogxK
M3 - Article
VL - 652
SP - 177
EP - 180
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -