Prognostic characteristics of MACC1 expression in epithelial ovarian cancer

Hoiseon Jeong; Jiyoon Jung; Hwa Eun Oh; Jung Woo Choi; Eung Seok Lee; Young Sik Kim; Ju Han Lee

doi:10.1155/2018/9207153

Prognostic characteristics of MACC1 expression in epithelial ovarian cancer

Hoiseon Jeong, Jiyoon Jung, Hwa Eun Oh, Jung Woo Choi, Eung Seok Lee, Young Sik Kim, Ju Han Lee

Department of Pathology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients. We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7). Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.

Original language	English
Article number	9207153
Journal	BioMed Research International
Volume	2018
DOIs	https://doi.org/10.1155/2018/9207153
Publication status	Published - 2018

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1155/2018/9207153

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title = "Prognostic characteristics of MACC1 expression in epithelial ovarian cancer",

abstract = "Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients. We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7). Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.",

author = "Hoiseon Jeong and Jiyoon Jung and Oh, {Hwa Eun} and Choi, {Jung Woo} and Lee, {Eung Seok} and Kim, {Young Sik} and Lee, {Ju Han}",

note = "Funding Information: This work was supported by Korea University Ansan Hospital Grant (O1801191). Publisher Copyright: Copyright {\textcopyright} 2018 Hoiseon Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2018",

doi = "10.1155/2018/9207153",

language = "English",

volume = "2018",

journal = "BioMed Research International",

issn = "2314-6133",

publisher = "Hindawi Publishing Corporation",

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AU - Jeong, Hoiseon

AU - Jung, Jiyoon

AU - Oh, Hwa Eun

AU - Choi, Jung Woo

AU - Lee, Eung Seok

AU - Kim, Young Sik

AU - Lee, Ju Han

N1 - Funding Information: This work was supported by Korea University Ansan Hospital Grant (O1801191). Publisher Copyright: Copyright © 2018 Hoiseon Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2018

Y1 - 2018

N2 - Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients. We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7). Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.

AB - Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients. We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7). Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.

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Prognostic characteristics of MACC1 expression in epithelial ovarian cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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