Abstract
Purpose: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Patients and Methods: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Results: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24. 1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. Conclusions: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.
| Original language | English |
|---|---|
| Pages (from-to) | 598-607 |
| Number of pages | 10 |
| Journal | Journal of Gastrointestinal Surgery |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Apr 1 |
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Keywords
- 10-Year survival
- HBeAg
- Hepatocellular carcinoma
- Tumor size
ASJC Scopus subject areas
- Surgery
- Gastroenterology
Cite this
Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy. / Kim, Sung Hoon; Choi, Sae-Byeol; Lee, Jae Gil; Kim, Seung Up; Park, Mi Suk; Kim, Do Young; Choi, Jin Sub; Kim, Kyung Sik.
In: Journal of Gastrointestinal Surgery, Vol. 15, No. 4, 01.04.2011, p. 598-607.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy
AU - Kim, Sung Hoon
AU - Choi, Sae-Byeol
AU - Lee, Jae Gil
AU - Kim, Seung Up
AU - Park, Mi Suk
AU - Kim, Do Young
AU - Choi, Jin Sub
AU - Kim, Kyung Sik
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Purpose: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Patients and Methods: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Results: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24. 1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. Conclusions: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.
AB - Purpose: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Patients and Methods: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Results: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24. 1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. Conclusions: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.
KW - 10-Year survival
KW - HBeAg
KW - Hepatocellular carcinoma
KW - Tumor size
UR - http://www.scopus.com/inward/record.url?scp=79953120380&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953120380&partnerID=8YFLogxK
U2 - 10.1007/s11605-011-1452-7
DO - 10.1007/s11605-011-1452-7
M3 - Article
C2 - 21336497
AN - SCOPUS:79953120380
VL - 15
SP - 598
EP - 607
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
SN - 1091-255X
IS - 4
ER -