Prognostic factors of community-acquired bacteremic patients with severe sepsis: A prospective, observational study

Young Kyung Yoon, Ja Kim Min, Dae Won Park, Soon Sun Kwon, Byung-Chul Chun, Hee-Jin Cheong, Jun Yong Choi, Hee Jung Choi, Young Hwa Choi, Hyo Youl Kim, Joong Sik Eom, Sang Il Kim, Young Goo Song, Kyong Ran Peck, Yang Soo Kim, June Myung Kim, Jang Wook Sohn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Characterization of clinical features of bacteremic severe sepsis acquired from the community has been inadequate; therefore, our goal in this study was to identify prognostic factors associated with outcome in patients with community-acquired bacteremic severe sepsis. Materials and Methods: Adult patients (≥18 years) with community-acquired severe sepsis in whom pathogens were identified from blood cultures were included in the study. Data were collected prospectively from 12 teaching hospitals between May, 2005, and February, 2009. Data included demographic characteristics, co-morbid medical conditions, primary infection sites, sepsis severity, mortality, causative microorganisms, and the appropriateness of initial empirical antibiotic therapy. Results: During the study period, 1,152 patients were diagnosed with communityacquired severe sepsis and 422 patients were found to harbor pathogens in their blood. Among the 422 patients analyzed, 253 (60.0%) patients went into shock and 121 patients (28.7%) died during hospitalization. Risk factors, including respiratory tract infection (odds ratio [OR], 2.60; 95% confidence interval [CI], 1.11-6.09), number of organ dysfunctions (OR, 1.39; 95% CI, 1.13-1.71), and higher APACHE II scores (OR, 1.08; 95% CI, 1.03-1.13) showed an association with poor survival, whereas Escherichia coli as a pathogen (OR, 0.31; 95% CI, 0.16-0.64) showed an association with lower mortality. Conclusions: In addition to severity of illness, the primary site of infection and causative microorganisms were also identified as important prognostic factors in patients with community-acquired bacteremic severe sepsis.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalInfection and Chemotherapy
Volume44
Issue number3
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

Observational Studies
Sepsis
Prospective Studies
Odds Ratio
Confidence Intervals
APACHE
Mortality
Infection
Teaching Hospitals
Respiratory Tract Infections
Shock
Hospitalization
Demography
Escherichia coli
Anti-Bacterial Agents
Survival

Keywords

  • Bacteremia
  • Community-acquired infections
  • Prognostic factors
  • Septic shock
  • Severe sepsis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Prognostic factors of community-acquired bacteremic patients with severe sepsis : A prospective, observational study. / Yoon, Young Kyung; Min, Ja Kim; Park, Dae Won; Kwon, Soon Sun; Chun, Byung-Chul; Cheong, Hee-Jin; Choi, Jun Yong; Choi, Hee Jung; Choi, Young Hwa; Kim, Hyo Youl; Eom, Joong Sik; Kim, Sang Il; Song, Young Goo; Peck, Kyong Ran; Kim, Yang Soo; Kim, June Myung; Sohn, Jang Wook.

In: Infection and Chemotherapy, Vol. 44, No. 3, 01.06.2012, p. 168-174.

Research output: Contribution to journalArticle

Yoon, Young Kyung ; Min, Ja Kim ; Park, Dae Won ; Kwon, Soon Sun ; Chun, Byung-Chul ; Cheong, Hee-Jin ; Choi, Jun Yong ; Choi, Hee Jung ; Choi, Young Hwa ; Kim, Hyo Youl ; Eom, Joong Sik ; Kim, Sang Il ; Song, Young Goo ; Peck, Kyong Ran ; Kim, Yang Soo ; Kim, June Myung ; Sohn, Jang Wook. / Prognostic factors of community-acquired bacteremic patients with severe sepsis : A prospective, observational study. In: Infection and Chemotherapy. 2012 ; Vol. 44, No. 3. pp. 168-174.
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T1 - Prognostic factors of community-acquired bacteremic patients with severe sepsis

T2 - A prospective, observational study

AU - Yoon, Young Kyung

AU - Min, Ja Kim

AU - Park, Dae Won

AU - Kwon, Soon Sun

AU - Chun, Byung-Chul

AU - Cheong, Hee-Jin

AU - Choi, Jun Yong

AU - Choi, Hee Jung

AU - Choi, Young Hwa

AU - Kim, Hyo Youl

AU - Eom, Joong Sik

AU - Kim, Sang Il

AU - Song, Young Goo

AU - Peck, Kyong Ran

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AU - Kim, June Myung

AU - Sohn, Jang Wook

PY - 2012/6/1

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N2 - Background: Characterization of clinical features of bacteremic severe sepsis acquired from the community has been inadequate; therefore, our goal in this study was to identify prognostic factors associated with outcome in patients with community-acquired bacteremic severe sepsis. Materials and Methods: Adult patients (≥18 years) with community-acquired severe sepsis in whom pathogens were identified from blood cultures were included in the study. Data were collected prospectively from 12 teaching hospitals between May, 2005, and February, 2009. Data included demographic characteristics, co-morbid medical conditions, primary infection sites, sepsis severity, mortality, causative microorganisms, and the appropriateness of initial empirical antibiotic therapy. Results: During the study period, 1,152 patients were diagnosed with communityacquired severe sepsis and 422 patients were found to harbor pathogens in their blood. Among the 422 patients analyzed, 253 (60.0%) patients went into shock and 121 patients (28.7%) died during hospitalization. Risk factors, including respiratory tract infection (odds ratio [OR], 2.60; 95% confidence interval [CI], 1.11-6.09), number of organ dysfunctions (OR, 1.39; 95% CI, 1.13-1.71), and higher APACHE II scores (OR, 1.08; 95% CI, 1.03-1.13) showed an association with poor survival, whereas Escherichia coli as a pathogen (OR, 0.31; 95% CI, 0.16-0.64) showed an association with lower mortality. Conclusions: In addition to severity of illness, the primary site of infection and causative microorganisms were also identified as important prognostic factors in patients with community-acquired bacteremic severe sepsis.

AB - Background: Characterization of clinical features of bacteremic severe sepsis acquired from the community has been inadequate; therefore, our goal in this study was to identify prognostic factors associated with outcome in patients with community-acquired bacteremic severe sepsis. Materials and Methods: Adult patients (≥18 years) with community-acquired severe sepsis in whom pathogens were identified from blood cultures were included in the study. Data were collected prospectively from 12 teaching hospitals between May, 2005, and February, 2009. Data included demographic characteristics, co-morbid medical conditions, primary infection sites, sepsis severity, mortality, causative microorganisms, and the appropriateness of initial empirical antibiotic therapy. Results: During the study period, 1,152 patients were diagnosed with communityacquired severe sepsis and 422 patients were found to harbor pathogens in their blood. Among the 422 patients analyzed, 253 (60.0%) patients went into shock and 121 patients (28.7%) died during hospitalization. Risk factors, including respiratory tract infection (odds ratio [OR], 2.60; 95% confidence interval [CI], 1.11-6.09), number of organ dysfunctions (OR, 1.39; 95% CI, 1.13-1.71), and higher APACHE II scores (OR, 1.08; 95% CI, 1.03-1.13) showed an association with poor survival, whereas Escherichia coli as a pathogen (OR, 0.31; 95% CI, 0.16-0.64) showed an association with lower mortality. Conclusions: In addition to severity of illness, the primary site of infection and causative microorganisms were also identified as important prognostic factors in patients with community-acquired bacteremic severe sepsis.

KW - Bacteremia

KW - Community-acquired infections

KW - Prognostic factors

KW - Septic shock

KW - Severe sepsis

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