Prognostic impact of low skeletal muscle mass on major adverse cardiovascular events in coronary artery disease: A propensity score-matched analysis of a single center all-comer cohort

Dong Oh Kang, So Yeon Park, Byoung Geol Choi, Jin Oh Na, Cheol Ung Choi, Eung Ju Kim, Seung Woon Rha, Chang Gyu Park, Suk Joo Hong, Hong Seog Seo

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29 Citations (Scopus)

Abstract

The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm2/m2, female <25.00 cm2/m2) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%, p < 0.001) and MACEs (39.6% vs. 11.8%, p < 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95–8.45; p < 0.001) and MACEs (HR: 3.76; 95% CI: 2.27–6.23; p < 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.

Original languageEnglish
Article number712
JournalJournal of Clinical Medicine
Volume8
Issue number5
DOIs
Publication statusPublished - 2019 May

Keywords

  • Cardiovascular disease
  • Computed tomography
  • Coronary artery disease
  • L1 SMI
  • Percutaneous coronary intervention
  • Sarcopenia
  • Skeletal muscle index

ASJC Scopus subject areas

  • Medicine(all)

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