Prognostic impact of the combination of the neutrophil-to-lymphocyte ratio and serum carbohydrate antigen 19-9 in patients with pancreas head cancer

Wan Joon Kim, Tae Wan Lim, Pyoung Jae Park, Sae Byeol Choi, Wan Bae Kim

Research output: Contribution to journalArticle

Abstract

Background: This study aimed to evaluate the clinical value of the combination of a traditional prognostic factor with a systemic inflammation-based prognostic factor in patients undergoing curative resection for pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma. Methods: From January 2005 to December 2015, 198 patients were enrolled. Various clinicopathological factors potentially associated with survival and recurrence were evaluated in this study. Results: The selected cut-off values for the test prognostic factors with sufficient sensitivity and specificity were 2.8 for the neutrophil-to-lymphocyte ratio (NLR) and 70 U/mL for serum carbohydrate antigen 19-9 (CA19-9). Kaplan–Meier survival analysis demonstrated that the 5-year survival rate in patients with a high NLR and CA19-9 was 21.8% compared with 79.8% for patients with a low NLR and CA19-9. The 5-year disease-free survival rate in patients with a high NLR and CA19-9 was 0% compared with 33.9% for patients with a low NLR and CA19-9. Patients with high NLRs and high CA19-9 were more likely to have an early recurrence and multiple relapse patterns. Conclusion: Preoperative NLR and serum CA19-9 offer significant prognostic information for survival following curative resection of pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma.

Original languageEnglish
Pages (from-to)E302-E307
JournalANZ Journal of Surgery
Volume89
Issue number7
DOIs
Publication statusPublished - 2019 Jan 1

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Head and Neck Neoplasms
Pancreatic Neoplasms
Neutrophils
Carbohydrates
Lymphocytes
Antigens
Serum
Recurrence
Adenocarcinoma
Survival Rate
Survival
Survival Analysis
Disease-Free Survival
Inflammation
Sensitivity and Specificity

Keywords

  • carbohydrate antigen 19-9
  • neutrophil-to-lymphocyte ratio
  • pancreas head cancer

ASJC Scopus subject areas

  • Surgery

Cite this

Prognostic impact of the combination of the neutrophil-to-lymphocyte ratio and serum carbohydrate antigen 19-9 in patients with pancreas head cancer. / Kim, Wan Joon; Lim, Tae Wan; Park, Pyoung Jae; Choi, Sae Byeol; Kim, Wan Bae.

In: ANZ Journal of Surgery, Vol. 89, No. 7, 01.01.2019, p. E302-E307.

Research output: Contribution to journalArticle

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abstract = "Background: This study aimed to evaluate the clinical value of the combination of a traditional prognostic factor with a systemic inflammation-based prognostic factor in patients undergoing curative resection for pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma. Methods: From January 2005 to December 2015, 198 patients were enrolled. Various clinicopathological factors potentially associated with survival and recurrence were evaluated in this study. Results: The selected cut-off values for the test prognostic factors with sufficient sensitivity and specificity were 2.8 for the neutrophil-to-lymphocyte ratio (NLR) and 70 U/mL for serum carbohydrate antigen 19-9 (CA19-9). Kaplan–Meier survival analysis demonstrated that the 5-year survival rate in patients with a high NLR and CA19-9 was 21.8{\%} compared with 79.8{\%} for patients with a low NLR and CA19-9. The 5-year disease-free survival rate in patients with a high NLR and CA19-9 was 0{\%} compared with 33.9{\%} for patients with a low NLR and CA19-9. Patients with high NLRs and high CA19-9 were more likely to have an early recurrence and multiple relapse patterns. Conclusion: Preoperative NLR and serum CA19-9 offer significant prognostic information for survival following curative resection of pancreas head cancer diagnosed as pancreatic ductal adenocarcinoma.",
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AU - Kim, Wan Bae

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