Prognostic role of copeptin after stroke: A systematic review and meta-Analysis of observational studies

Kyu Sun Choi, Hyun Jung Kim, Hyoung Joon Chun, Jae Min Kim, Hyeong Joong Yi, Jin Hwan Cheong, Choong Hyun Kim, Suck Jun Oh, Yong Ko, Young Soo Kim, Koang Hum Bak, Je Il Ryu, Wonhee Kim, Taeho Lim, Hyeong Sik Ahn, Il Min Ahn, Seon Heui Lee

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Abstract

Copeptin, the C-Terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-Analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-Analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.

Original languageEnglish
Article number11665
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015 Jun 29

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ASJC Scopus subject areas

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Choi, K. S., Kim, H. J., Chun, H. J., Kim, J. M., Yi, H. J., Cheong, J. H., Kim, C. H., Oh, S. J., Ko, Y., Kim, Y. S., Bak, K. H., Ryu, J. I., Kim, W., Lim, T., Ahn, H. S., Ahn, I. M., & Lee, S. H. (2015). Prognostic role of copeptin after stroke: A systematic review and meta-Analysis of observational studies. Scientific Reports, 5, [11665]. https://doi.org/10.1038/srep11665