Prognostic role of copeptin after stroke: A systematic review and meta-Analysis of observational studies

Kyu Sun Choi, Hyun Jung Kim, Hyoung Joon Chun, Jae Min Kim, Hyeong Joong Yi, Jin Hwan Cheong, Choong Hyun Kim, Suck Jun Oh, Yong Ko, Young Soo Kim, Koang Hum Bak, Je Il Ryu, Wonhee Kim, Taeho Lim, Hyeong Sik Ahn, Il Min Ahn, Seon Heui Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Copeptin, the C-Terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-Analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-Analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.

Original languageEnglish
Article number11665
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 2015 Jun 29

Fingerprint

Observational Studies
Meta-Analysis
Stroke
Mortality
copeptins
Survivors

ASJC Scopus subject areas

  • General

Cite this

Choi, K. S., Kim, H. J., Chun, H. J., Kim, J. M., Yi, H. J., Cheong, J. H., ... Lee, S. H. (2015). Prognostic role of copeptin after stroke: A systematic review and meta-Analysis of observational studies. Scientific Reports, 5, [11665]. https://doi.org/10.1038/srep11665

Prognostic role of copeptin after stroke : A systematic review and meta-Analysis of observational studies. / Choi, Kyu Sun; Kim, Hyun Jung; Chun, Hyoung Joon; Kim, Jae Min; Yi, Hyeong Joong; Cheong, Jin Hwan; Kim, Choong Hyun; Oh, Suck Jun; Ko, Yong; Kim, Young Soo; Bak, Koang Hum; Ryu, Je Il; Kim, Wonhee; Lim, Taeho; Ahn, Hyeong Sik; Ahn, Il Min; Lee, Seon Heui.

In: Scientific Reports, Vol. 5, 11665, 29.06.2015.

Research output: Contribution to journalArticle

Choi, KS, Kim, HJ, Chun, HJ, Kim, JM, Yi, HJ, Cheong, JH, Kim, CH, Oh, SJ, Ko, Y, Kim, YS, Bak, KH, Ryu, JI, Kim, W, Lim, T, Ahn, HS, Ahn, IM & Lee, SH 2015, 'Prognostic role of copeptin after stroke: A systematic review and meta-Analysis of observational studies', Scientific Reports, vol. 5, 11665. https://doi.org/10.1038/srep11665
Choi, Kyu Sun ; Kim, Hyun Jung ; Chun, Hyoung Joon ; Kim, Jae Min ; Yi, Hyeong Joong ; Cheong, Jin Hwan ; Kim, Choong Hyun ; Oh, Suck Jun ; Ko, Yong ; Kim, Young Soo ; Bak, Koang Hum ; Ryu, Je Il ; Kim, Wonhee ; Lim, Taeho ; Ahn, Hyeong Sik ; Ahn, Il Min ; Lee, Seon Heui. / Prognostic role of copeptin after stroke : A systematic review and meta-Analysis of observational studies. In: Scientific Reports. 2015 ; Vol. 5.
@article{5113beaa3d534e7c91c7dcefe242cd2f,
title = "Prognostic role of copeptin after stroke: A systematic review and meta-Analysis of observational studies",
abstract = "Copeptin, the C-Terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-Analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95{\%} CI, 1.44-2.19 and OR 3.90; 95{\%} CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95{\%} CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-Analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.",
author = "Choi, {Kyu Sun} and Kim, {Hyun Jung} and Chun, {Hyoung Joon} and Kim, {Jae Min} and Yi, {Hyeong Joong} and Cheong, {Jin Hwan} and Kim, {Choong Hyun} and Oh, {Suck Jun} and Yong Ko and Kim, {Young Soo} and Bak, {Koang Hum} and Ryu, {Je Il} and Wonhee Kim and Taeho Lim and Ahn, {Hyeong Sik} and Ahn, {Il Min} and Lee, {Seon Heui}",
year = "2015",
month = "6",
day = "29",
doi = "10.1038/srep11665",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Prognostic role of copeptin after stroke

T2 - A systematic review and meta-Analysis of observational studies

AU - Choi, Kyu Sun

AU - Kim, Hyun Jung

AU - Chun, Hyoung Joon

AU - Kim, Jae Min

AU - Yi, Hyeong Joong

AU - Cheong, Jin Hwan

AU - Kim, Choong Hyun

AU - Oh, Suck Jun

AU - Ko, Yong

AU - Kim, Young Soo

AU - Bak, Koang Hum

AU - Ryu, Je Il

AU - Kim, Wonhee

AU - Lim, Taeho

AU - Ahn, Hyeong Sik

AU - Ahn, Il Min

AU - Lee, Seon Heui

PY - 2015/6/29

Y1 - 2015/6/29

N2 - Copeptin, the C-Terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-Analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-Analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.

AB - Copeptin, the C-Terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-Analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44-2.19 and OR 3.90; 95% CI 3.07-4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36-2.03). A stratified analysis by study region showed significant differences in SMD of copeptin, and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-Analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.

UR - http://www.scopus.com/inward/record.url?scp=84934276065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84934276065&partnerID=8YFLogxK

U2 - 10.1038/srep11665

DO - 10.1038/srep11665

M3 - Article

C2 - 26119473

AN - SCOPUS:84934276065

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 11665

ER -