Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction

Young Joon Hong, Myung Ho Jeong, Dae Woo Hyun, Seung Ho Hur, Kwon Bae Kim, Weon Kim, Sang Yeob Lim, Sang Hyun Lee, Seo Na Hong, Dong Goo Kang, Kyung Ho Yun, Kye Hun Kim, Yun Sang Lee, Hyung Wook Park, Ju Han Kim, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang

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Abstract

We prospectively followed 202 patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%). Patients were divided into 2 groups: groups I (simvastatin group, n = 106, aged 60.8 ± 10.3 years, men 71.7%) and II (non-simvastatin group, n = 96, aged 60.9 ± 10.4 years, men 78.1%). During 1-year clinical follow-up, simvastatin therapy was associated with a significant reduction in mortality (1.9% vs 7.5%, p = 0.048), restenosis rate (25.7% vs 43.1%, p = 0.033), and repeat PCI rate (25.7% vs 43.1%, p = 0.033), and with significant improvement in LV ejection fraction (31% to 42% vs 32% to 39%, p = 0.042). The event-free survival rate was higher in group I than in group II (79.8% vs 57.0%, p = 0.001). In conclusion, simvastatin therapy improves LV systolic function and decreases mortality, restenosis, and repeat PCI rate in patients with ischemic heart failure who underwent PCI for acute myocardial infarction.

Original languageEnglish
Pages (from-to)619-622
Number of pages4
JournalAmerican Journal of Cardiology
Volume95
Issue number5
DOIs
Publication statusPublished - 2005 Mar 1
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, Y. J., Jeong, M. H., Hyun, D. W., Hur, S. H., Kim, K. B., Kim, W., Lim, S. Y., Lee, S. H., Hong, S. N., Kang, D. G., Yun, K. H., Kim, K. H., Lee, Y. S., Park, H. W., Kim, J. H., Ahn, Y. K., Cho, J. G., Park, J. C., & Kang, J. C. (2005). Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction. American Journal of Cardiology, 95(5), 619-622. https://doi.org/10.1016/j.amjcard.2004.10.039