Prognostic significance of tumour progression and human papillomavirus in advanced tonsillar cancer classified as stage IVa

E. Park, Kwang-Yoon Jung, Soon Young Kwon, Jeong-Soo Woo, Jae-Gu Cho, M. W. Park, I. S. Kim, S. J. Kim, Seung-Kuk Baek

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To identify clinical factors that can explain the differences in treatment outcome, and examine the value of human papillomavirus infection as a prognostic biomarker in stage IVa tonsillar carcinomas. Methods: Fifty-nine patients with tonsillar carcinoma classified as stage IVa were retrospectively analysed for survival outcomes according to various clinical factors. Human papillomavirus infection was evaluated using a human papillomavirus DNA chip test and immunohistochemical staining for p16 and p53. Results: Lower disease-free survival rates were associated with increasing local invasiveness and nodal status. Although human papillomavirus positivity and p16 expression was more common in locally advanced tonsillar carcinomas with advanced nodal status, the overall survival rate was better for patients with human papillomavirus positive, p16-positive tumours. Conclusion: The disease-free survival rate may differ according to local tumour invasiveness and nodal status, even for stage IVa tonsillar cancers. Human papillomavirus infection may be a useful biomarker for predicting treatment outcomes for stage VIa tumours.

Original languageEnglish
Pages (from-to)86-92
Number of pages7
JournalJournal of Laryngology and Otology
Volume129
Issue number1
DOIs
Publication statusPublished - 2015 Jan 10

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Tonsillar Neoplasms
Papillomavirus Infections
Survival Rate
Neoplasms
Carcinoma
Disease-Free Survival
Human Papillomavirus DNA Tests
Biomarkers
Oligonucleotide Array Sequence Analysis
Staining and Labeling
Survival

Keywords

  • Neoplasm Staging
  • P16INK4 Protein
  • P53 Tumor Suppressor Protein
  • Papillomavirus Infections
  • Prognosis
  • Tonsillar Neoplasms

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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abstract = "Objective: To identify clinical factors that can explain the differences in treatment outcome, and examine the value of human papillomavirus infection as a prognostic biomarker in stage IVa tonsillar carcinomas. Methods: Fifty-nine patients with tonsillar carcinoma classified as stage IVa were retrospectively analysed for survival outcomes according to various clinical factors. Human papillomavirus infection was evaluated using a human papillomavirus DNA chip test and immunohistochemical staining for p16 and p53. Results: Lower disease-free survival rates were associated with increasing local invasiveness and nodal status. Although human papillomavirus positivity and p16 expression was more common in locally advanced tonsillar carcinomas with advanced nodal status, the overall survival rate was better for patients with human papillomavirus positive, p16-positive tumours. Conclusion: The disease-free survival rate may differ according to local tumour invasiveness and nodal status, even for stage IVa tonsillar cancers. Human papillomavirus infection may be a useful biomarker for predicting treatment outcomes for stage VIa tumours.",
keywords = "Neoplasm Staging, P16INK4 Protein, P53 Tumor Suppressor Protein, Papillomavirus Infections, Prognosis, Tonsillar Neoplasms",
author = "E. Park and Kwang-Yoon Jung and Kwon, {Soon Young} and Jeong-Soo Woo and Jae-Gu Cho and Park, {M. W.} and Kim, {I. S.} and Kim, {S. J.} and Seung-Kuk Baek",
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AU - Park, E.

AU - Jung, Kwang-Yoon

AU - Kwon, Soon Young

AU - Woo, Jeong-Soo

AU - Cho, Jae-Gu

AU - Park, M. W.

AU - Kim, I. S.

AU - Kim, S. J.

AU - Baek, Seung-Kuk

PY - 2015/1/10

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N2 - Objective: To identify clinical factors that can explain the differences in treatment outcome, and examine the value of human papillomavirus infection as a prognostic biomarker in stage IVa tonsillar carcinomas. Methods: Fifty-nine patients with tonsillar carcinoma classified as stage IVa were retrospectively analysed for survival outcomes according to various clinical factors. Human papillomavirus infection was evaluated using a human papillomavirus DNA chip test and immunohistochemical staining for p16 and p53. Results: Lower disease-free survival rates were associated with increasing local invasiveness and nodal status. Although human papillomavirus positivity and p16 expression was more common in locally advanced tonsillar carcinomas with advanced nodal status, the overall survival rate was better for patients with human papillomavirus positive, p16-positive tumours. Conclusion: The disease-free survival rate may differ according to local tumour invasiveness and nodal status, even for stage IVa tonsillar cancers. Human papillomavirus infection may be a useful biomarker for predicting treatment outcomes for stage VIa tumours.

AB - Objective: To identify clinical factors that can explain the differences in treatment outcome, and examine the value of human papillomavirus infection as a prognostic biomarker in stage IVa tonsillar carcinomas. Methods: Fifty-nine patients with tonsillar carcinoma classified as stage IVa were retrospectively analysed for survival outcomes according to various clinical factors. Human papillomavirus infection was evaluated using a human papillomavirus DNA chip test and immunohistochemical staining for p16 and p53. Results: Lower disease-free survival rates were associated with increasing local invasiveness and nodal status. Although human papillomavirus positivity and p16 expression was more common in locally advanced tonsillar carcinomas with advanced nodal status, the overall survival rate was better for patients with human papillomavirus positive, p16-positive tumours. Conclusion: The disease-free survival rate may differ according to local tumour invasiveness and nodal status, even for stage IVa tonsillar cancers. Human papillomavirus infection may be a useful biomarker for predicting treatment outcomes for stage VIa tumours.

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KW - Prognosis

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