Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma

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21 Citations (Scopus)

Abstract

Objectives/Hypothesis: Regional lymph node metastases are very common findings of supraglottic cancer. The mechanism of lymphatic metastasis is as yet unknown because there have been no specific markers that could definitely distinguish lymphatic vessels from blood vessels. The aim of this study is to identify the prognostic significance of vascular endothelial growth factor-C (VEGF-C) expression and lymphatic vessel density (LVD) in supraglottic cancer. Study Design: The prognostic value of the VEGF-C and LVD was retrospectively evaluated in an unselected series of patients treated with curative intent for supraglottic cancer. Methods: We investigated lymphatic vessels in 43 subjects who had previously been diagnosed with supraglottic cancer. Immunohistochemical staining was performed with VEGF-C, D2-40, and CD31 monoclonal antibodies on the paraffin-embedded tissues obtained from these patients. The association among the semiquantitative score of VEGF-C stained cancer cells, the density of immunohistochemically stained microvessels, and the prognostic factors of supraglottic cancers were investigated to evaluate the prognostic significance. Results: VEGF-C and LVD showed a statistically significant difference according to the presence of lymph node metastasis and regional recurrence (P <.05). VEGF-C was only associated with disease-free survival and regional recurrence in multivariate analysis (P <.05). Conclusions: VEGF-C and LVD might be useful as predictors of the risk of lymph node metastasis and regional recurrence.

Original languageEnglish
Pages (from-to)1325-1330
Number of pages6
JournalLaryngoscope
Volume119
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1

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Vascular Endothelial Growth Factor C
Lymphatic Vessels
Squamous Cell Carcinoma
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Recurrence
Lymphatic Metastasis
Microvessels
Paraffin
Disease-Free Survival
Blood Vessels
Multivariate Analysis
Cell Count
Staining and Labeling

Keywords

  • Lymphangiogenesis
  • Lymphatic metastasis
  • Regional recurrence
  • Supraglottic cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

@article{2cd1b53ce60c442fa0a2bc175d129034,
title = "Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma",
abstract = "Objectives/Hypothesis: Regional lymph node metastases are very common findings of supraglottic cancer. The mechanism of lymphatic metastasis is as yet unknown because there have been no specific markers that could definitely distinguish lymphatic vessels from blood vessels. The aim of this study is to identify the prognostic significance of vascular endothelial growth factor-C (VEGF-C) expression and lymphatic vessel density (LVD) in supraglottic cancer. Study Design: The prognostic value of the VEGF-C and LVD was retrospectively evaluated in an unselected series of patients treated with curative intent for supraglottic cancer. Methods: We investigated lymphatic vessels in 43 subjects who had previously been diagnosed with supraglottic cancer. Immunohistochemical staining was performed with VEGF-C, D2-40, and CD31 monoclonal antibodies on the paraffin-embedded tissues obtained from these patients. The association among the semiquantitative score of VEGF-C stained cancer cells, the density of immunohistochemically stained microvessels, and the prognostic factors of supraglottic cancers were investigated to evaluate the prognostic significance. Results: VEGF-C and LVD showed a statistically significant difference according to the presence of lymph node metastasis and regional recurrence (P <.05). VEGF-C was only associated with disease-free survival and regional recurrence in multivariate analysis (P <.05). Conclusions: VEGF-C and LVD might be useful as predictors of the risk of lymph node metastasis and regional recurrence.",
keywords = "Lymphangiogenesis, Lymphatic metastasis, Regional recurrence, Supraglottic cancer",
author = "Seung-Kuk Baek and Kwang-Yoon Jung and Lee, {Sang Hag} and Jeong-Soo Woo and Kwon, {Soon Young} and Chung, {Eun Jae} and Tae-Hoon Kim and Chae, {Yang Seok}",
year = "2009",
month = "7",
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doi = "10.1002/lary.20483",
language = "English",
volume = "119",
pages = "1325--1330",
journal = "Laryngoscope",
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TY - JOUR

T1 - Prognostic significance of vascular endothelial growth factor-C expression and lymphatic vessel density in supraglottic squamous cell carcinoma

AU - Baek, Seung-Kuk

AU - Jung, Kwang-Yoon

AU - Lee, Sang Hag

AU - Woo, Jeong-Soo

AU - Kwon, Soon Young

AU - Chung, Eun Jae

AU - Kim, Tae-Hoon

AU - Chae, Yang Seok

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Objectives/Hypothesis: Regional lymph node metastases are very common findings of supraglottic cancer. The mechanism of lymphatic metastasis is as yet unknown because there have been no specific markers that could definitely distinguish lymphatic vessels from blood vessels. The aim of this study is to identify the prognostic significance of vascular endothelial growth factor-C (VEGF-C) expression and lymphatic vessel density (LVD) in supraglottic cancer. Study Design: The prognostic value of the VEGF-C and LVD was retrospectively evaluated in an unselected series of patients treated with curative intent for supraglottic cancer. Methods: We investigated lymphatic vessels in 43 subjects who had previously been diagnosed with supraglottic cancer. Immunohistochemical staining was performed with VEGF-C, D2-40, and CD31 monoclonal antibodies on the paraffin-embedded tissues obtained from these patients. The association among the semiquantitative score of VEGF-C stained cancer cells, the density of immunohistochemically stained microvessels, and the prognostic factors of supraglottic cancers were investigated to evaluate the prognostic significance. Results: VEGF-C and LVD showed a statistically significant difference according to the presence of lymph node metastasis and regional recurrence (P <.05). VEGF-C was only associated with disease-free survival and regional recurrence in multivariate analysis (P <.05). Conclusions: VEGF-C and LVD might be useful as predictors of the risk of lymph node metastasis and regional recurrence.

AB - Objectives/Hypothesis: Regional lymph node metastases are very common findings of supraglottic cancer. The mechanism of lymphatic metastasis is as yet unknown because there have been no specific markers that could definitely distinguish lymphatic vessels from blood vessels. The aim of this study is to identify the prognostic significance of vascular endothelial growth factor-C (VEGF-C) expression and lymphatic vessel density (LVD) in supraglottic cancer. Study Design: The prognostic value of the VEGF-C and LVD was retrospectively evaluated in an unselected series of patients treated with curative intent for supraglottic cancer. Methods: We investigated lymphatic vessels in 43 subjects who had previously been diagnosed with supraglottic cancer. Immunohistochemical staining was performed with VEGF-C, D2-40, and CD31 monoclonal antibodies on the paraffin-embedded tissues obtained from these patients. The association among the semiquantitative score of VEGF-C stained cancer cells, the density of immunohistochemically stained microvessels, and the prognostic factors of supraglottic cancers were investigated to evaluate the prognostic significance. Results: VEGF-C and LVD showed a statistically significant difference according to the presence of lymph node metastasis and regional recurrence (P <.05). VEGF-C was only associated with disease-free survival and regional recurrence in multivariate analysis (P <.05). Conclusions: VEGF-C and LVD might be useful as predictors of the risk of lymph node metastasis and regional recurrence.

KW - Lymphangiogenesis

KW - Lymphatic metastasis

KW - Regional recurrence

KW - Supraglottic cancer

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