TY - JOUR
T1 - Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes
T2 - a nationwide population-based study
AU - Lee, Da Young
AU - Han, Kyungdo
AU - Yu, Ji Hee
AU - Park, Sanghyun
AU - Seo, Ji A.
AU - Kim, Nam Hoon
AU - Yoo, Hye Jin
AU - Kim, Sin Gon
AU - Kim, Seon Mee
AU - Choi, Kyung Mook
AU - Baik, Sei Hyun
AU - Park, Yong Gyu
AU - Kim, Nan Hee
N1 - Funding Information:
This research was supported by a National Research Foundation of Korea grant funded by the Korean government (MSIP) (No. 2015R1A2A2A01003167, 2015R1C1A2A01052010) and by a Korea University Ansan Hospital Grant (O1801361). The funders were not involved in the study’s design or reporting.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - We examined whether long-term gamma-glutamyl transferase (GGT) variability can predict cardiovascular disease (CVD) and mortality in individuals with diabetes. We included 698,937 Koreans diabetes patients older than 40 years without histories of CVD, chronic liver disease, or heavy alcoholics who received health exams supported by the Korean government more than once in 2009–2012 (baseline). We used Cox proportional analyses to estimate the risk of stroke, myocardial infarction (MI), and all-cause mortality until December 31, 2016, according to the quartiles of the average successive variability (ASV) of GGT measured during the five years before the baseline. A total 26,119, 15,103, and 39,982 cases of stroke, MI, and death, respectively, were found. GGT ASV quartile 4 had a significantly higher risk of stroke and all-cause mortality than quartile 1, with adjustment for risk factors, such as baseline glucose and GGT level, and comorbidities. Hazard ratios (95% confidence intervals) for GGT ASV quartile 4 were 1.06 (1.03–1.10) and 1.23 (1.20–1.27) for stroke and mortality, respectively. This significant association was shown consistently across the baseline GGT quartiles. GGT variability was related to the risk of stroke and all-cause mortality. The effect was most pronounced in all-cause mortality, irrespective of baseline GGT level.
AB - We examined whether long-term gamma-glutamyl transferase (GGT) variability can predict cardiovascular disease (CVD) and mortality in individuals with diabetes. We included 698,937 Koreans diabetes patients older than 40 years without histories of CVD, chronic liver disease, or heavy alcoholics who received health exams supported by the Korean government more than once in 2009–2012 (baseline). We used Cox proportional analyses to estimate the risk of stroke, myocardial infarction (MI), and all-cause mortality until December 31, 2016, according to the quartiles of the average successive variability (ASV) of GGT measured during the five years before the baseline. A total 26,119, 15,103, and 39,982 cases of stroke, MI, and death, respectively, were found. GGT ASV quartile 4 had a significantly higher risk of stroke and all-cause mortality than quartile 1, with adjustment for risk factors, such as baseline glucose and GGT level, and comorbidities. Hazard ratios (95% confidence intervals) for GGT ASV quartile 4 were 1.06 (1.03–1.10) and 1.23 (1.20–1.27) for stroke and mortality, respectively. This significant association was shown consistently across the baseline GGT quartiles. GGT variability was related to the risk of stroke and all-cause mortality. The effect was most pronounced in all-cause mortality, irrespective of baseline GGT level.
UR - http://www.scopus.com/inward/record.url?scp=85091269608&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-72318-7
DO - 10.1038/s41598-020-72318-7
M3 - Article
C2 - 32958798
AN - SCOPUS:85091269608
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 15375
ER -
