Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer

Hyun Hoon Chung, Jae Weon Kim, Kyung Hee Han, Jae Seon Eo, Keon Wook Kang, Noh Hyun Park, Yong Sang Song, June Key Chung, Soon Beom Kang

Research output: Contribution to journalArticle

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Abstract

Objective: To determine if preoperative metabolic tumor volume (MTV) measured by integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. Methods: Patients with FIGO stage IB to IIA cervical cancer were imaged with FDG-PET/CT before radical surgery. MTV was measured from attenuation-corrected FDG-PET/CT images using a standard uptake value (SUV)-based automated contouring program. We evaluated the relationship of MTV to disease-free survival (DFS). Results: A total of 63 patients were included in the study. The cut-off value for predicting recurrence was determined using a receiver operating characteristic (ROC) curve. MTV in this study was found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUVmax. In univariate analysis, MTV ≥ 23.4 mL (HR 1.017, 95% confidence interval (CI) 1.005-1.029, P = 0.004), SUVmax ≥ 9.5 (HR 5.198, 95% CI 1.076-25.118, P = 0.04), LN metastasis (HR 12.338, 95% CI 1.541-98.813, P = 0.018), PM involvement (HR 14.274, 95% CI 1.785-114.149, P = 0.012), and lymphovascular space invasion (HR 8.871, 95% CI 1.104-71.261, P = 0.04), were related to DFS. In multivariate analyses, age (HR 0.748, 95% CI 0.587-0.952, P = 0.018) and MTV ≥ 23.4 mL (HR 49.559, 95% CI 1.257-1953.399, P = 0.037) were determined to be independent prognostic factors of DFS. Conclusion: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery.

Original languageEnglish
Pages (from-to)270-274
Number of pages5
JournalGynecologic Oncology
Volume120
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1
Externally publishedYes

Fingerprint

Tumor Burden
Uterine Cervical Neoplasms
Confidence Intervals
Disease-Free Survival
Peritoneum
Lymph Nodes
Neoplasm Metastasis
Fluorodeoxyglucose F18
Hysterectomy
ROC Curve
Multivariate Analysis
Recurrence

Keywords

  • Cervical cancer
  • Metabolic tumor volume
  • PET/CT
  • Recurrence
  • Surgery

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer. / Chung, Hyun Hoon; Kim, Jae Weon; Han, Kyung Hee; Eo, Jae Seon; Kang, Keon Wook; Park, Noh Hyun; Song, Yong Sang; Chung, June Key; Kang, Soon Beom.

In: Gynecologic Oncology, Vol. 120, No. 2, 01.02.2011, p. 270-274.

Research output: Contribution to journalArticle

Chung, HH, Kim, JW, Han, KH, Eo, JS, Kang, KW, Park, NH, Song, YS, Chung, JK & Kang, SB 2011, 'Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer', Gynecologic Oncology, vol. 120, no. 2, pp. 270-274. https://doi.org/10.1016/j.ygyno.2010.11.002
Chung, Hyun Hoon ; Kim, Jae Weon ; Han, Kyung Hee ; Eo, Jae Seon ; Kang, Keon Wook ; Park, Noh Hyun ; Song, Yong Sang ; Chung, June Key ; Kang, Soon Beom. / Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer. In: Gynecologic Oncology. 2011 ; Vol. 120, No. 2. pp. 270-274.
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abstract = "Objective: To determine if preoperative metabolic tumor volume (MTV) measured by integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. Methods: Patients with FIGO stage IB to IIA cervical cancer were imaged with FDG-PET/CT before radical surgery. MTV was measured from attenuation-corrected FDG-PET/CT images using a standard uptake value (SUV)-based automated contouring program. We evaluated the relationship of MTV to disease-free survival (DFS). Results: A total of 63 patients were included in the study. The cut-off value for predicting recurrence was determined using a receiver operating characteristic (ROC) curve. MTV in this study was found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUVmax. In univariate analysis, MTV ≥ 23.4 mL (HR 1.017, 95{\%} confidence interval (CI) 1.005-1.029, P = 0.004), SUVmax ≥ 9.5 (HR 5.198, 95{\%} CI 1.076-25.118, P = 0.04), LN metastasis (HR 12.338, 95{\%} CI 1.541-98.813, P = 0.018), PM involvement (HR 14.274, 95{\%} CI 1.785-114.149, P = 0.012), and lymphovascular space invasion (HR 8.871, 95{\%} CI 1.104-71.261, P = 0.04), were related to DFS. In multivariate analyses, age (HR 0.748, 95{\%} CI 0.587-0.952, P = 0.018) and MTV ≥ 23.4 mL (HR 49.559, 95{\%} CI 1.257-1953.399, P = 0.037) were determined to be independent prognostic factors of DFS. Conclusion: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery.",
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author = "Chung, {Hyun Hoon} and Kim, {Jae Weon} and Han, {Kyung Hee} and Eo, {Jae Seon} and Kang, {Keon Wook} and Park, {Noh Hyun} and Song, {Yong Sang} and Chung, {June Key} and Kang, {Soon Beom}",
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T1 - Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer

AU - Chung, Hyun Hoon

AU - Kim, Jae Weon

AU - Han, Kyung Hee

AU - Eo, Jae Seon

AU - Kang, Keon Wook

AU - Park, Noh Hyun

AU - Song, Yong Sang

AU - Chung, June Key

AU - Kang, Soon Beom

PY - 2011/2/1

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N2 - Objective: To determine if preoperative metabolic tumor volume (MTV) measured by integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. Methods: Patients with FIGO stage IB to IIA cervical cancer were imaged with FDG-PET/CT before radical surgery. MTV was measured from attenuation-corrected FDG-PET/CT images using a standard uptake value (SUV)-based automated contouring program. We evaluated the relationship of MTV to disease-free survival (DFS). Results: A total of 63 patients were included in the study. The cut-off value for predicting recurrence was determined using a receiver operating characteristic (ROC) curve. MTV in this study was found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUVmax. In univariate analysis, MTV ≥ 23.4 mL (HR 1.017, 95% confidence interval (CI) 1.005-1.029, P = 0.004), SUVmax ≥ 9.5 (HR 5.198, 95% CI 1.076-25.118, P = 0.04), LN metastasis (HR 12.338, 95% CI 1.541-98.813, P = 0.018), PM involvement (HR 14.274, 95% CI 1.785-114.149, P = 0.012), and lymphovascular space invasion (HR 8.871, 95% CI 1.104-71.261, P = 0.04), were related to DFS. In multivariate analyses, age (HR 0.748, 95% CI 0.587-0.952, P = 0.018) and MTV ≥ 23.4 mL (HR 49.559, 95% CI 1.257-1953.399, P = 0.037) were determined to be independent prognostic factors of DFS. Conclusion: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery.

AB - Objective: To determine if preoperative metabolic tumor volume (MTV) measured by integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. Methods: Patients with FIGO stage IB to IIA cervical cancer were imaged with FDG-PET/CT before radical surgery. MTV was measured from attenuation-corrected FDG-PET/CT images using a standard uptake value (SUV)-based automated contouring program. We evaluated the relationship of MTV to disease-free survival (DFS). Results: A total of 63 patients were included in the study. The cut-off value for predicting recurrence was determined using a receiver operating characteristic (ROC) curve. MTV in this study was found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUVmax. In univariate analysis, MTV ≥ 23.4 mL (HR 1.017, 95% confidence interval (CI) 1.005-1.029, P = 0.004), SUVmax ≥ 9.5 (HR 5.198, 95% CI 1.076-25.118, P = 0.04), LN metastasis (HR 12.338, 95% CI 1.541-98.813, P = 0.018), PM involvement (HR 14.274, 95% CI 1.785-114.149, P = 0.012), and lymphovascular space invasion (HR 8.871, 95% CI 1.104-71.261, P = 0.04), were related to DFS. In multivariate analyses, age (HR 0.748, 95% CI 0.587-0.952, P = 0.018) and MTV ≥ 23.4 mL (HR 49.559, 95% CI 1.257-1953.399, P = 0.037) were determined to be independent prognostic factors of DFS. Conclusion: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery.

KW - Cervical cancer

KW - Metabolic tumor volume

KW - PET/CT

KW - Recurrence

KW - Surgery

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