Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma: A large, multicenter cohort analysis

Sumin Son, Eu Chang Hwang, Seung Il Jung, Dong Deuk Kwon, Seock Hwan Choi, Tae Gyun Kwon, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul Sung Kim, Sung-Gu Kang, Jun Cheon, Hong Koo Ha, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: The aim of this study was to investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated. Univariable and multivariable analysis was performed using the Cox proportional hazards regression model. Cut-off values for NLR and PLR were calculated using a receiver operating characteristic curve. RESULTS: The median follow-up period was 39.1 (interquartile range: 18.3-63.8) months. Univariable analysis revealed that GPS, mGPS, PLR, and NLR (all, P=0.001) were significantly associated with both recurrence-free survival (RFS) and cancer-specific survival (CSS). Multivariable analysis revealed that GPS (P=0.001), PLR (hazards ratio [HR] =1.32; 95% CI: 1.08-1.62, P=0.007 and HR =1.87; 95% CI: 1.21-2.92, P=0.005), NLR (HR =1.38; 95% CI: 1.12-1.69, P=0.003 and HR =1.70; 95% CI: 1.10-2.62, P=0.017) were significantly associated with RFS and CSS. CONCLUSIONS: Our results suggest that preoperative systemic inflammation markers such as GPS, PLR, and NLR are independent prognostic factors in patients with UTUC after surgery.

Original languageEnglish
Pages (from-to)300-309
Number of pages10
JournalMinerva Urologica e Nefrologica
Volume70
Issue number3
DOIs
Publication statusPublished - 2018 Jun 1

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Large Cell Carcinoma
Cohort Studies
Lymphocytes
Inflammation
Neutrophils
Blood Platelets
Survival
Carcinoma
Recurrence
Proportional Hazards Models
ROC Curve
Neoplasms
Urinary Bladder

Keywords

  • Carcinoma
  • Inflammation
  • Prognosis
  • Transitional cell

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma : A large, multicenter cohort analysis. / Son, Sumin; Hwang, Eu Chang; Jung, Seung Il; Kwon, Dong Deuk; Choi, Seock Hwan; Kwon, Tae Gyun; Noh, Joon Hwa; Kim, Myung Ki; Seo, Ill Young; Kim, Chul Sung; Kang, Sung-Gu; Cheon, Jun; Ha, Hong Koo; Jeong, Chang Wook; Ku, Ja Hyeon; Kwak, Cheol; Kim, Hyeon Hoe.

In: Minerva Urologica e Nefrologica, Vol. 70, No. 3, 01.06.2018, p. 300-309.

Research output: Contribution to journalArticle

Son, S, Hwang, EC, Jung, SI, Kwon, DD, Choi, SH, Kwon, TG, Noh, JH, Kim, MK, Seo, IY, Kim, CS, Kang, S-G, Cheon, J, Ha, HK, Jeong, CW, Ku, JH, Kwak, C & Kim, HH 2018, 'Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma: A large, multicenter cohort analysis', Minerva Urologica e Nefrologica, vol. 70, no. 3, pp. 300-309. https://doi.org/10.23736/S0393-2249.18.02914-4
Son, Sumin ; Hwang, Eu Chang ; Jung, Seung Il ; Kwon, Dong Deuk ; Choi, Seock Hwan ; Kwon, Tae Gyun ; Noh, Joon Hwa ; Kim, Myung Ki ; Seo, Ill Young ; Kim, Chul Sung ; Kang, Sung-Gu ; Cheon, Jun ; Ha, Hong Koo ; Jeong, Chang Wook ; Ku, Ja Hyeon ; Kwak, Cheol ; Kim, Hyeon Hoe. / Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma : A large, multicenter cohort analysis. In: Minerva Urologica e Nefrologica. 2018 ; Vol. 70, No. 3. pp. 300-309.
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abstract = "BACKGROUND: The aim of this study was to investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated. Univariable and multivariable analysis was performed using the Cox proportional hazards regression model. Cut-off values for NLR and PLR were calculated using a receiver operating characteristic curve. RESULTS: The median follow-up period was 39.1 (interquartile range: 18.3-63.8) months. Univariable analysis revealed that GPS, mGPS, PLR, and NLR (all, P=0.001) were significantly associated with both recurrence-free survival (RFS) and cancer-specific survival (CSS). Multivariable analysis revealed that GPS (P=0.001), PLR (hazards ratio [HR] =1.32; 95{\%} CI: 1.08-1.62, P=0.007 and HR =1.87; 95{\%} CI: 1.21-2.92, P=0.005), NLR (HR =1.38; 95{\%} CI: 1.12-1.69, P=0.003 and HR =1.70; 95{\%} CI: 1.10-2.62, P=0.017) were significantly associated with RFS and CSS. CONCLUSIONS: Our results suggest that preoperative systemic inflammation markers such as GPS, PLR, and NLR are independent prognostic factors in patients with UTUC after surgery.",
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T1 - Prognostic value of preoperative systemic inflammation markers in localized upper tract urothelial cell carcinoma

T2 - A large, multicenter cohort analysis

AU - Son, Sumin

AU - Hwang, Eu Chang

AU - Jung, Seung Il

AU - Kwon, Dong Deuk

AU - Choi, Seock Hwan

AU - Kwon, Tae Gyun

AU - Noh, Joon Hwa

AU - Kim, Myung Ki

AU - Seo, Ill Young

AU - Kim, Chul Sung

AU - Kang, Sung-Gu

AU - Cheon, Jun

AU - Ha, Hong Koo

AU - Jeong, Chang Wook

AU - Ku, Ja Hyeon

AU - Kwak, Cheol

AU - Kim, Hyeon Hoe

PY - 2018/6/1

Y1 - 2018/6/1

N2 - BACKGROUND: The aim of this study was to investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated. Univariable and multivariable analysis was performed using the Cox proportional hazards regression model. Cut-off values for NLR and PLR were calculated using a receiver operating characteristic curve. RESULTS: The median follow-up period was 39.1 (interquartile range: 18.3-63.8) months. Univariable analysis revealed that GPS, mGPS, PLR, and NLR (all, P=0.001) were significantly associated with both recurrence-free survival (RFS) and cancer-specific survival (CSS). Multivariable analysis revealed that GPS (P=0.001), PLR (hazards ratio [HR] =1.32; 95% CI: 1.08-1.62, P=0.007 and HR =1.87; 95% CI: 1.21-2.92, P=0.005), NLR (HR =1.38; 95% CI: 1.12-1.69, P=0.003 and HR =1.70; 95% CI: 1.10-2.62, P=0.017) were significantly associated with RFS and CSS. CONCLUSIONS: Our results suggest that preoperative systemic inflammation markers such as GPS, PLR, and NLR are independent prognostic factors in patients with UTUC after surgery.

AB - BACKGROUND: The aim of this study was to investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated. Univariable and multivariable analysis was performed using the Cox proportional hazards regression model. Cut-off values for NLR and PLR were calculated using a receiver operating characteristic curve. RESULTS: The median follow-up period was 39.1 (interquartile range: 18.3-63.8) months. Univariable analysis revealed that GPS, mGPS, PLR, and NLR (all, P=0.001) were significantly associated with both recurrence-free survival (RFS) and cancer-specific survival (CSS). Multivariable analysis revealed that GPS (P=0.001), PLR (hazards ratio [HR] =1.32; 95% CI: 1.08-1.62, P=0.007 and HR =1.87; 95% CI: 1.21-2.92, P=0.005), NLR (HR =1.38; 95% CI: 1.12-1.69, P=0.003 and HR =1.70; 95% CI: 1.10-2.62, P=0.017) were significantly associated with RFS and CSS. CONCLUSIONS: Our results suggest that preoperative systemic inflammation markers such as GPS, PLR, and NLR are independent prognostic factors in patients with UTUC after surgery.

KW - Carcinoma

KW - Inflammation

KW - Prognosis

KW - Transitional cell

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