Abstract
Aim The aim of this study was to determine the most relevant parameters of fluorine-18 fluorodeoxyglucose (18 F-FDG) PET/computed tomography (CT) for predicting recurrence in patients with locally advanced cervical cancer. Materials and methods Fifty-six patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IVA cervical cancer who underwent 18 F-FDG PET/CT before definitive chemoradiotherapy were retrospectively enrolled. Various PET parameters, namely, maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, were analyzed to evaluate the relationship between these PET parameters and recurrence-free survival (RFS). The cut-off values of PET parameters that showed the best trade-off between sensitivity and specificity for RFS were determined by receiver operating characteristic curve analysis. Results The median follow-up was 20 months (range, 6-63 months). Univariate analysis indicated that higher FIGO stage [hazard ratio (HR) 5.606, 95% confidence interval (CI) 1.682-18.68, P=0.005], metabolic tumor volume more than 47.81 cm3 (HR 6.203, 95% CI 1.351-28.481, P=0.019), and TLG more than 215.02 (HR 11.817, 95% CI 1.518-91.963, P=0.018) were associated with RFS. In multivariate analysis, FIGO stage (HR 4.618, 95% CI 1.295-16.463, P=0.018) and TLG more than 215.02 (HR 10.171, 95% CI 1.246-83.044, P=0.030) were independent predictive factors for RFS. Kaplan-Meier curves for RFS indicated that patients with TLG less than or equal to 215.02 showed better RFS (P=0.003). Conclusion Pretreatment TLG proved to be an independent prognostic factor for RFS in patients with locally advanced cervical cancer treated by definitive chemoradiotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 843-848 |
| Number of pages | 6 |
| Journal | Nuclear Medicine Communications |
| Volume | 37 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2016 Aug 1 |
Fingerprint
Keywords
- F-FDG PET/CT
- cervical cancer
- recurrence
- survival
- total lesion glycolysis
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Prognostic value of total lesion glycolysis measured by 18F-FDG PET/CT in patients with locally advanced cervical cancer. / Hong, Jin-Hwa; Jung, Un Suk; Min, Kyung Jin; Lee, Jae Kwan; Kim, Sungeun; Eo, Jae Seon.
In: Nuclear Medicine Communications, Vol. 37, No. 8, 01.08.2016, p. 843-848.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic value of total lesion glycolysis measured by 18F-FDG PET/CT in patients with locally advanced cervical cancer
AU - Hong, Jin-Hwa
AU - Jung, Un Suk
AU - Min, Kyung Jin
AU - Lee, Jae Kwan
AU - Kim, Sungeun
AU - Eo, Jae Seon
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Aim The aim of this study was to determine the most relevant parameters of fluorine-18 fluorodeoxyglucose (18 F-FDG) PET/computed tomography (CT) for predicting recurrence in patients with locally advanced cervical cancer. Materials and methods Fifty-six patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IVA cervical cancer who underwent 18 F-FDG PET/CT before definitive chemoradiotherapy were retrospectively enrolled. Various PET parameters, namely, maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, were analyzed to evaluate the relationship between these PET parameters and recurrence-free survival (RFS). The cut-off values of PET parameters that showed the best trade-off between sensitivity and specificity for RFS were determined by receiver operating characteristic curve analysis. Results The median follow-up was 20 months (range, 6-63 months). Univariate analysis indicated that higher FIGO stage [hazard ratio (HR) 5.606, 95% confidence interval (CI) 1.682-18.68, P=0.005], metabolic tumor volume more than 47.81 cm3 (HR 6.203, 95% CI 1.351-28.481, P=0.019), and TLG more than 215.02 (HR 11.817, 95% CI 1.518-91.963, P=0.018) were associated with RFS. In multivariate analysis, FIGO stage (HR 4.618, 95% CI 1.295-16.463, P=0.018) and TLG more than 215.02 (HR 10.171, 95% CI 1.246-83.044, P=0.030) were independent predictive factors for RFS. Kaplan-Meier curves for RFS indicated that patients with TLG less than or equal to 215.02 showed better RFS (P=0.003). Conclusion Pretreatment TLG proved to be an independent prognostic factor for RFS in patients with locally advanced cervical cancer treated by definitive chemoradiotherapy.
AB - Aim The aim of this study was to determine the most relevant parameters of fluorine-18 fluorodeoxyglucose (18 F-FDG) PET/computed tomography (CT) for predicting recurrence in patients with locally advanced cervical cancer. Materials and methods Fifty-six patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB to IVA cervical cancer who underwent 18 F-FDG PET/CT before definitive chemoradiotherapy were retrospectively enrolled. Various PET parameters, namely, maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, were analyzed to evaluate the relationship between these PET parameters and recurrence-free survival (RFS). The cut-off values of PET parameters that showed the best trade-off between sensitivity and specificity for RFS were determined by receiver operating characteristic curve analysis. Results The median follow-up was 20 months (range, 6-63 months). Univariate analysis indicated that higher FIGO stage [hazard ratio (HR) 5.606, 95% confidence interval (CI) 1.682-18.68, P=0.005], metabolic tumor volume more than 47.81 cm3 (HR 6.203, 95% CI 1.351-28.481, P=0.019), and TLG more than 215.02 (HR 11.817, 95% CI 1.518-91.963, P=0.018) were associated with RFS. In multivariate analysis, FIGO stage (HR 4.618, 95% CI 1.295-16.463, P=0.018) and TLG more than 215.02 (HR 10.171, 95% CI 1.246-83.044, P=0.030) were independent predictive factors for RFS. Kaplan-Meier curves for RFS indicated that patients with TLG less than or equal to 215.02 showed better RFS (P=0.003). Conclusion Pretreatment TLG proved to be an independent prognostic factor for RFS in patients with locally advanced cervical cancer treated by definitive chemoradiotherapy.
KW - F-FDG PET/CT
KW - cervical cancer
KW - recurrence
KW - survival
KW - total lesion glycolysis
UR - http://www.scopus.com/inward/record.url?scp=84964053103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964053103&partnerID=8YFLogxK
U2 - 10.1097/MNM.0000000000000516
DO - 10.1097/MNM.0000000000000516
M3 - Article
C2 - 27058362
AN - SCOPUS:84964053103
VL - 37
SP - 843
EP - 848
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
SN - 0143-3636
IS - 8
ER -