Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): Additive effect on apoptosis via caspase-3 dependent pathway

Jeong Heon Lee, Seung Bae Rho, Taehoon Chun

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Programmed cell death 6 (PDCD6) protein is a 22 kDa EF-hand type Ca 2+-binding protein involved in apoptosis. To define the regulating mechanism of PDCD6 activity in the apoptotic pathway, we searched a human ovary cDNA library for a novel PDCD6 binding protein using a yeast two-hybrid system. The selected protein was the human death-associated protein kinase 1 (DAPk1), another protein that functions as a positive mediator of apoptosis. Co-transfection of PDCD6 and DAPk1 cDNA into a tumor cell line accelerated apoptosis via caspase-3 dependent pathway.

Original languageEnglish
Pages (from-to)1011-1015
Number of pages5
JournalBiotechnology letters
Volume27
Issue number14
DOIs
Publication statusPublished - 2005 Jul
Externally publishedYes

Keywords

  • Apoptosis
  • Caspase
  • Death-associated protein kinase 1
  • Programmed cell death 6
  • Yeast two hybrid

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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