Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1)

Additive effect on apoptosis via caspase-3 dependent pathway

Jeong Heon Lee, Seung Bae Rho, Taehoon Chun

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Programmed cell death 6 (PDCD6) protein is a 22 kDa EF-hand type Ca 2+-binding protein involved in apoptosis. To define the regulating mechanism of PDCD6 activity in the apoptotic pathway, we searched a human ovary cDNA library for a novel PDCD6 binding protein using a yeast two-hybrid system. The selected protein was the human death-associated protein kinase 1 (DAPk1), another protein that functions as a positive mediator of apoptosis. Co-transfection of PDCD6 and DAPk1 cDNA into a tumor cell line accelerated apoptosis via caspase-3 dependent pathway.

Original languageEnglish
Pages (from-to)1011-1015
Number of pages5
JournalBiotechnology Letters
Volume27
Issue number14
DOIs
Publication statusPublished - 2005 Jul 1
Externally publishedYes

Fingerprint

Death-Associated Protein Kinases
Apoptosis Regulatory Proteins
Cell death
Caspase 3
Cell Death
Apoptosis
Proteins
EF Hand Motifs
Two-Hybrid System Techniques
Tumor Cell Line
Gene Library
Transfection
Ovary
Carrier Proteins
Complementary DNA
Hybrid systems
Yeast
Tumors
Cells

Keywords

  • Apoptosis
  • Caspase
  • Death-associated protein kinase 1
  • Programmed cell death 6
  • Yeast two hybrid

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1) : Additive effect on apoptosis via caspase-3 dependent pathway. / Lee, Jeong Heon; Rho, Seung Bae; Chun, Taehoon.

In: Biotechnology Letters, Vol. 27, No. 14, 01.07.2005, p. 1011-1015.

Research output: Contribution to journalArticle

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