Abstract
During development, elimination of excess cells through programmed cell death (PCD) is essential for the establishment and maintenance of the nervous system. In many brain regions, development and major histogenesis continue beyond postnatal stages, and therefore, signs of neurogenesis and PCD are frequently observed in these postnatal brain regions. Furthermore, some brain regions maintain neurogenic potential throughout life, and continuous genesis and PCD play critical roles in sculpting these adult neural circuits. Although similar regulatory mechanisms that control PCD during development appear to also control PCD in the adult brain, adult-generated neurons must integrate into mature neural circuits for their survival. This novel requirement appears to result in unique features of PCD in the adult brain. In this article, we summarize recent findings related to PCD in the early postnatal and adult brain in rodents.
| Original language | English |
|---|---|
| Pages (from-to) | 225-235 |
| Number of pages | 11 |
| Journal | Development Growth and Differentiation |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 Feb 1 |
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Keywords
- Adult neurogenesis
- Cell death
- Dentate gyrus
- Olfactory bulb
- Postnatal development
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
Cite this
Programmed cell death during postnatal development of the rodent nervous system. / Kim, Woon Ryoung; Sun, Woong.
In: Development Growth and Differentiation, Vol. 53, No. 2, 01.02.2011, p. 225-235.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Programmed cell death during postnatal development of the rodent nervous system
AU - Kim, Woon Ryoung
AU - Sun, Woong
PY - 2011/2/1
Y1 - 2011/2/1
N2 - During development, elimination of excess cells through programmed cell death (PCD) is essential for the establishment and maintenance of the nervous system. In many brain regions, development and major histogenesis continue beyond postnatal stages, and therefore, signs of neurogenesis and PCD are frequently observed in these postnatal brain regions. Furthermore, some brain regions maintain neurogenic potential throughout life, and continuous genesis and PCD play critical roles in sculpting these adult neural circuits. Although similar regulatory mechanisms that control PCD during development appear to also control PCD in the adult brain, adult-generated neurons must integrate into mature neural circuits for their survival. This novel requirement appears to result in unique features of PCD in the adult brain. In this article, we summarize recent findings related to PCD in the early postnatal and adult brain in rodents.
AB - During development, elimination of excess cells through programmed cell death (PCD) is essential for the establishment and maintenance of the nervous system. In many brain regions, development and major histogenesis continue beyond postnatal stages, and therefore, signs of neurogenesis and PCD are frequently observed in these postnatal brain regions. Furthermore, some brain regions maintain neurogenic potential throughout life, and continuous genesis and PCD play critical roles in sculpting these adult neural circuits. Although similar regulatory mechanisms that control PCD during development appear to also control PCD in the adult brain, adult-generated neurons must integrate into mature neural circuits for their survival. This novel requirement appears to result in unique features of PCD in the adult brain. In this article, we summarize recent findings related to PCD in the early postnatal and adult brain in rodents.
KW - Adult neurogenesis
KW - Cell death
KW - Dentate gyrus
KW - Olfactory bulb
KW - Postnatal development
UR - http://www.scopus.com/inward/record.url?scp=79951818254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951818254&partnerID=8YFLogxK
U2 - 10.1111/j.1440-169X.2010.01226.x
DO - 10.1111/j.1440-169X.2010.01226.x
M3 - Article
VL - 53
SP - 225
EP - 235
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
SN - 0012-1592
IS - 2
ER -