Abstract
Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.
Original language | English |
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Pages (from-to) | 257-262 |
Number of pages | 6 |
Journal | Cell Biology International |
Volume | 31 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2007 Mar |
Keywords
- CD1d-restricted NKT cell
- Cell cycle
- Co-receptor
- LAG-3
ASJC Scopus subject areas
- Cell Biology