Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase

Hyun Jung Byun; Woon Won Jung; Dong Sup Lee; Sanghee Kim; Sang Joon Kim; Chung Gyu Park; Hee Yong Chung; Taehoon Chun

doi:10.1016/j.cellbi.2006.11.002

Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase

Hyun Jung Byun, Woon Won Jung, Dong Sup Lee, Sanghee Kim, Sang Joon Kim, Chung Gyu Park, Hee Yong Chung, Taehoon Chun

Department of Biotechnology

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.

Original language	English
Pages (from-to)	257-262
Number of pages	6
Journal	Cell Biology International
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.cellbi.2006.11.002
Publication status	Published - 2007 Mar

Keywords

CD1d-restricted NKT cell
Cell cycle
Co-receptor
LAG-3

ASJC Scopus subject areas

Cell Biology

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Byun, H. J., Jung, W. W., Lee, D. S., Kim, S., Kim, S. J., Park, C. G., Chung, H. Y., & Chun, T. (2007). Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase. Cell Biology International, 31(3), 257-262. https://doi.org/10.1016/j.cellbi.2006.11.002

Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase. / Byun, Hyun Jung; Jung, Woon Won; Lee, Dong Sup; Kim, Sanghee; Kim, Sang Joon; Park, Chung Gyu; Chung, Hee Yong; Chun, Taehoon.

In: Cell Biology International, Vol. 31, No. 3, 03.2007, p. 257-262.

Research output: Contribution to journal › Article

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abstract = "Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.",

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