Proliferation of activated CD1d-restricted NKT cells is down-modulated by lymphocyte activation gene-3 signaling via cell cycle arrest in S phase

Hyun Jung Byun, Woon Won Jung, Dong Sup Lee, Sanghee Kim, Sang Joon Kim, Chung Gyu Park, Hee Yong Chung, Taehoon Chun

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Upon antigenic stimulation, CD1d-restricted NKT cells quickly secrete large amounts of cytokines. This prompt response demonstrates that CD1d-restricted NKT cells may potentially prove to be useful therapeutic agents for the treatment of many diseases. Despite the clinical importance of CD1d-restricted NKT cells, the regulating mechanisms of this unique T cell population remain to be defined. We found murine LAG-3 is inducible on CD1d-restricted NKT cells as the result of a variety of stimulants such as concanavalin A (con A) and anti-CD3. Also, antigen-specific CD1d stimulation can elicit LAG-3 in CD1d-restricted NKT cells. Moreover, ectopic LAG-3 expression on CD1d-restricted NKT cells results in cell cycle arrest in the S phase. These results show that LAG-3 signaling on activated CD1d-restricted NKT cells may down-modulate NKT cell proliferation.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalCell Biology International
Volume31
Issue number3
DOIs
Publication statusPublished - 2007 Mar

Keywords

  • CD1d-restricted NKT cell
  • Cell cycle
  • Co-receptor
  • LAG-3

ASJC Scopus subject areas

  • Cell Biology

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