Prolonged administration enhances the renoprotective effect of pentoxifylline via anti-inflammatory activity in streptozotocin-induced diabetic nephropathy

Kum Hyun Han, Sang Youb Han, Han Seong Kim, Young Sun Kang, Dae Ryong Cha

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.

    Original languageEnglish
    Pages (from-to)137-143
    Number of pages7
    JournalInflammation
    Volume33
    Issue number3
    DOIs
    Publication statusPublished - 2010 Jun

    Keywords

    • Diabetic nephropathy
    • Inflammation
    • Pentoxifylline

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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