Prolonged administration enhances the renoprotective effect of pentoxifylline via anti-inflammatory activity in streptozotocin-induced diabetic nephropathy

Kum Hyun Han, Sang Youb Han, Han Seong Kim, Young Sun Kang, Dae-Ryong Cha

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The beneficial effects of pentoxifylline (PTX), which has an anti-inflammatory and renoprotective effect in diabetic nephropathy, are not completely understood. This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltration of ED-1 positive cells at 4 weeks. Further, in diabetic rats, administration of PTX for 4 weeks inhibited the renal inflammatory reaction, and when administration for 8 weeks, it prevented proteinuria. These findings support the hypothesis that prolonged administration enhances the protective effects of PTX.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalInflammation
Volume33
Issue number3
DOIs
Publication statusPublished - 2010 Jun 1

Fingerprint

Pentoxifylline
Diabetic Nephropathies
Streptozocin
Anti-Inflammatory Agents
Monocytes
Chemotactic Factors
Peptides
Proteinuria
Macrophages
Kidney
Antibodies
Proteins

Keywords

  • Diabetic nephropathy
  • Inflammation
  • Pentoxifylline

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Prolonged administration enhances the renoprotective effect of pentoxifylline via anti-inflammatory activity in streptozotocin-induced diabetic nephropathy. / Han, Kum Hyun; Han, Sang Youb; Kim, Han Seong; Kang, Young Sun; Cha, Dae-Ryong.

In: Inflammation, Vol. 33, No. 3, 01.06.2010, p. 137-143.

Research output: Contribution to journalArticle

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