Prolonged exposure to cigarette smoke blocks the neurotoxicity induced by kainic acid in rats

Hyoung Chun Kim, Wang Kee Jhoo, Kwang Ho Ko, Won-Ki Kim, Guoying Bing, Myung Sang Kwon, Eun Joo Shin, Jeong Hye Suh, Young Gu Lee, Dong Wook Lee

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We examined the effects of cigarette smoke (CS) on three parameters associated with kainic acid (KA)-induced neurotoxicity: seizure activity, cell loss in the hippocampus, and increased Fos-related antigen (FRA) expression. Animals were exposed to the main stream of CS from 15 Kentucky 2R1F research cigarettes containing 28.6 mg tar and 1.74 mg nicotine per cigarette, for 10 min a day, 6 days per week, for 4 weeks, using an automatic smoking machine. KA administration (10 mg/kg, i.p.) produced robust behavioral convulsions lasting 4-5 h. Pre-exposure to CS significantly reduced the seizures, mortality, and severe loss of cells in regions CA1 and CA3 of the hippocampus after KA administration. Consistently, pre-exposure to CS significantly attenuated the KA-induced increased FRA immunoreactivity in the hippocampus. In contrast, pre-treatment with central nicotinic antagonist, mecamylamine (2 or 10 mg/kg, i.p.) blocked the neuroprotective effects mediated by CS in a dose-dependent manner. These results indicate that CS exposure provides neuroprotection against the KA insult via nicotinic receptor activation.

Original languageEnglish
Pages (from-to)317-326
Number of pages10
JournalLife Sciences
Volume66
Issue number4
DOIs
Publication statusPublished - 1999 Dec 14
Externally publishedYes

Keywords

  • Cigarette smoke exposure
  • Fos-related antigen
  • Hippocampus
  • Kainic acid
  • Neuroprotection
  • Neurotoxicity
  • Nicotinic receptor

ASJC Scopus subject areas

  • Pharmacology

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