Abstract
Background and purpose: Although abnormal sleep duration is positively associated with increased risk for cardiovascular disease and mortality, the specific impact on intracerebral haemorrhage (ICH) risk remains unclear. The relationship between sleep duration and the risk of ICH was investigated in our study. Methods: A nationwide, multicentre matched case-control study was performed to investigate the risk factors for haemorrhagic stroke, using patients from 33 hospitals in Korea. In all, 490 patients with ICH and 980 age- and sex-matched controls were enrolled. Detailed information regarding sleep, sociodemographic factors, lifestyle and medical history before ICH onset was obtained using qualified structured questionnaires. Sleep duration was categorized and the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a conditional logistic regression with 7 h as the reference duration. Results: The number of subjects with long sleep duration, more than 8 h, was significantly greater in the ICH group than in the control group (≥8 h, 30.4% vs. 22.6%, P = 0.002). After controlling for relevant confounding factors, longer sleep duration was found to be independently associated with the risk of ICH in a dose-response manner (8 h, OR 1.57, 95% CI 1.00-2.47; ≥9 h, OR 5.00, 95% CI 2.18-11.47). Conclusions: Our study suggested that long sleep duration is positively associated with an increased ICH risk in a dose-dependent manner. Further studies on the relationship linking long sleep duration with increased risk of ICH are required.
| Original language | English |
|---|---|
| Pages (from-to) | 1036-1043 |
| Number of pages | 8 |
| Journal | European Journal of Neurology |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2016 Jun 1 |
| Externally published | Yes |
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Keywords
- Case-control study
- Intracerebral haemorrhage
- Lifestyle
- Long sleep duration
- Risk factors
- Sociodemographic factors
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Prolonged sleep increases the risk of intracerebral haemorrhage : A nationwide case-control study. / Kim, T. J.; Kim, Chi Kyung; Kim, Y.; Jung, S.; Jeong, H. G.; An, S. J.; Ko, S. B.; Yoon, B. W.
In: European Journal of Neurology, Vol. 23, No. 6, 01.06.2016, p. 1036-1043.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolonged sleep increases the risk of intracerebral haemorrhage
T2 - A nationwide case-control study
AU - Kim, T. J.
AU - Kim, Chi Kyung
AU - Kim, Y.
AU - Jung, S.
AU - Jeong, H. G.
AU - An, S. J.
AU - Ko, S. B.
AU - Yoon, B. W.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background and purpose: Although abnormal sleep duration is positively associated with increased risk for cardiovascular disease and mortality, the specific impact on intracerebral haemorrhage (ICH) risk remains unclear. The relationship between sleep duration and the risk of ICH was investigated in our study. Methods: A nationwide, multicentre matched case-control study was performed to investigate the risk factors for haemorrhagic stroke, using patients from 33 hospitals in Korea. In all, 490 patients with ICH and 980 age- and sex-matched controls were enrolled. Detailed information regarding sleep, sociodemographic factors, lifestyle and medical history before ICH onset was obtained using qualified structured questionnaires. Sleep duration was categorized and the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a conditional logistic regression with 7 h as the reference duration. Results: The number of subjects with long sleep duration, more than 8 h, was significantly greater in the ICH group than in the control group (≥8 h, 30.4% vs. 22.6%, P = 0.002). After controlling for relevant confounding factors, longer sleep duration was found to be independently associated with the risk of ICH in a dose-response manner (8 h, OR 1.57, 95% CI 1.00-2.47; ≥9 h, OR 5.00, 95% CI 2.18-11.47). Conclusions: Our study suggested that long sleep duration is positively associated with an increased ICH risk in a dose-dependent manner. Further studies on the relationship linking long sleep duration with increased risk of ICH are required.
AB - Background and purpose: Although abnormal sleep duration is positively associated with increased risk for cardiovascular disease and mortality, the specific impact on intracerebral haemorrhage (ICH) risk remains unclear. The relationship between sleep duration and the risk of ICH was investigated in our study. Methods: A nationwide, multicentre matched case-control study was performed to investigate the risk factors for haemorrhagic stroke, using patients from 33 hospitals in Korea. In all, 490 patients with ICH and 980 age- and sex-matched controls were enrolled. Detailed information regarding sleep, sociodemographic factors, lifestyle and medical history before ICH onset was obtained using qualified structured questionnaires. Sleep duration was categorized and the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a conditional logistic regression with 7 h as the reference duration. Results: The number of subjects with long sleep duration, more than 8 h, was significantly greater in the ICH group than in the control group (≥8 h, 30.4% vs. 22.6%, P = 0.002). After controlling for relevant confounding factors, longer sleep duration was found to be independently associated with the risk of ICH in a dose-response manner (8 h, OR 1.57, 95% CI 1.00-2.47; ≥9 h, OR 5.00, 95% CI 2.18-11.47). Conclusions: Our study suggested that long sleep duration is positively associated with an increased ICH risk in a dose-dependent manner. Further studies on the relationship linking long sleep duration with increased risk of ICH are required.
KW - Case-control study
KW - Intracerebral haemorrhage
KW - Lifestyle
KW - Long sleep duration
KW - Risk factors
KW - Sociodemographic factors
UR - http://www.scopus.com/inward/record.url?scp=84959507749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959507749&partnerID=8YFLogxK
U2 - 10.1111/ene.12978
DO - 10.1111/ene.12978
M3 - Article
C2 - 26945678
AN - SCOPUS:84959507749
VL - 23
SP - 1036
EP - 1043
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 6
ER -