Prolonged sleep increases the risk of intracerebral haemorrhage: A nationwide case-control study

T. J. Kim, Chi Kyung Kim, Y. Kim, S. Jung, H. G. Jeong, S. J. An, S. B. Ko, B. W. Yoon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and purpose: Although abnormal sleep duration is positively associated with increased risk for cardiovascular disease and mortality, the specific impact on intracerebral haemorrhage (ICH) risk remains unclear. The relationship between sleep duration and the risk of ICH was investigated in our study. Methods: A nationwide, multicentre matched case-control study was performed to investigate the risk factors for haemorrhagic stroke, using patients from 33 hospitals in Korea. In all, 490 patients with ICH and 980 age- and sex-matched controls were enrolled. Detailed information regarding sleep, sociodemographic factors, lifestyle and medical history before ICH onset was obtained using qualified structured questionnaires. Sleep duration was categorized and the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a conditional logistic regression with 7 h as the reference duration. Results: The number of subjects with long sleep duration, more than 8 h, was significantly greater in the ICH group than in the control group (≥8 h, 30.4% vs. 22.6%, P = 0.002). After controlling for relevant confounding factors, longer sleep duration was found to be independently associated with the risk of ICH in a dose-response manner (8 h, OR 1.57, 95% CI 1.00-2.47; ≥9 h, OR 5.00, 95% CI 2.18-11.47). Conclusions: Our study suggested that long sleep duration is positively associated with an increased ICH risk in a dose-dependent manner. Further studies on the relationship linking long sleep duration with increased risk of ICH are required.

Original languageEnglish
Pages (from-to)1036-1043
Number of pages8
JournalEuropean Journal of Neurology
Volume23
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1
Externally publishedYes

Fingerprint

Cerebral Hemorrhage
Case-Control Studies
Sleep
Odds Ratio
Confidence Intervals
Korea
Life Style
Cardiovascular Diseases
Logistic Models
Stroke
Control Groups
Mortality

Keywords

  • Case-control study
  • Intracerebral haemorrhage
  • Lifestyle
  • Long sleep duration
  • Risk factors
  • Sociodemographic factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Prolonged sleep increases the risk of intracerebral haemorrhage : A nationwide case-control study. / Kim, T. J.; Kim, Chi Kyung; Kim, Y.; Jung, S.; Jeong, H. G.; An, S. J.; Ko, S. B.; Yoon, B. W.

In: European Journal of Neurology, Vol. 23, No. 6, 01.06.2016, p. 1036-1043.

Research output: Contribution to journalArticle

Kim, T. J. ; Kim, Chi Kyung ; Kim, Y. ; Jung, S. ; Jeong, H. G. ; An, S. J. ; Ko, S. B. ; Yoon, B. W. / Prolonged sleep increases the risk of intracerebral haemorrhage : A nationwide case-control study. In: European Journal of Neurology. 2016 ; Vol. 23, No. 6. pp. 1036-1043.
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