Promotion of remyelination by sulfasalazine in a transgenic zebrafish model of demyelination

Suhyun Kim, Yun Il Lee, Ki Young Chang, Dong Won Lee, Sung Chun Cho, Young Wan Ha, Ji Eun Na, Im Joo Rhyu, Sang Chul Park, Hae Chul Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Most of the axons in the vertebrate nervous system are surrounded by a lipid-rich membrane called myelin, which promotes rapid conduction of nerve impulses and protects the axon from being damaged. Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS characterized by infiltration of immune cells and progressive damage to myelin and axons. One potential way to treat MS is to enhance the endogenous remyelination process, but at present there are no available treatments to promote remyelination in patients with demyelinating diseases. Sulfasalazine is an anti-inflammatory and immunemodulating drug that is used in rheumatology and inflammatory bowel disease. Its anti-inflammatory and immunomodulatory properties prompted us to test the ability of sulfasalazine to promote remyelination. In this study, we found that sulfasalazine promotes remyelination in the CNS of a transgenic zebrafish model of NTR/MTZ-induced demyelination. We also found that sulfasalazine treatment reduced the number of macrophages/microglia in the CNS of demyelinated zebrafish larvae, suggesting that the acceleration of remyelination is mediated by the immunomodulatory function of sulfasalazine. Our data suggest that temporal modulation of the immune response by sulfasalazine can be used to overcome MS by enhancing myelin repair and remyelination in the CNS.

Original languageEnglish
Pages (from-to)1013-1021
Number of pages9
JournalMolecules and Cells
Volume38
Issue number11
DOIs
Publication statusPublished - 2015

Fingerprint

Sulfasalazine
Demyelinating Diseases
Zebrafish
Myelin Sheath
Multiple Sclerosis
Axons
Anti-Inflammatory Agents
Rheumatology
Microglia
Membrane Lipids
Inflammatory Bowel Diseases
Nervous System
Action Potentials
Larva
Vertebrates
Chronic Disease
Macrophages
Therapeutics
Pharmaceutical Preparations

Keywords

  • Dorsal midline
  • Enhancer
  • EphA7

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Promotion of remyelination by sulfasalazine in a transgenic zebrafish model of demyelination. / Kim, Suhyun; Lee, Yun Il; Chang, Ki Young; Lee, Dong Won; Cho, Sung Chun; Ha, Young Wan; Na, Ji Eun; Rhyu, Im Joo; Park, Sang Chul; Park, Hae Chul.

In: Molecules and Cells, Vol. 38, No. 11, 2015, p. 1013-1021.

Research output: Contribution to journalArticle

Kim, Suhyun ; Lee, Yun Il ; Chang, Ki Young ; Lee, Dong Won ; Cho, Sung Chun ; Ha, Young Wan ; Na, Ji Eun ; Rhyu, Im Joo ; Park, Sang Chul ; Park, Hae Chul. / Promotion of remyelination by sulfasalazine in a transgenic zebrafish model of demyelination. In: Molecules and Cells. 2015 ; Vol. 38, No. 11. pp. 1013-1021.
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