Properties of the amniotic membrane may be applicable in cancer therapy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The amniotic membrane secretes various substances and has many functions, such as antiangiogenic activity, immunoregulatory activity, pro-apoptotic activity, antimicrobial properties, antifibroblastic activity, cell migration, and cell growth-promoting activity. Of these functions, we mainly focus on antiangiogenic activity, immunoregulatory activity, and pro-apoptotic activity and their applications in tumor biology. The amniotic membrane provides a privileged space anatomically, physiologically, and immunologically to the fetus. Angiogenesis occurs in tumor growth, and destruction of the immunologic barrier is an inevitable process in tumor invasion and metastasis. Regarding tumor cell killing, the pro-apoptotic pathway should be activated. Therefore, if we could apply the characteristics of the amniotic membrane to tumor biology, we might encounter a breakthrough in cancer treatment. For example, if a tumor mass could be enclosed by the amniotic membrane surgically, the growth of the tumor might be retarded. Further experiments and clinical trials should be conducted to verify our hypotheses.

Original languageEnglish
Pages (from-to)812-814
Number of pages3
JournalMedical Hypotheses
Volume70
Issue number4
DOIs
Publication statusPublished - 2008 Mar 5

Fingerprint

Amnion
Neoplasms
Therapeutics
Growth
Cell Movement
Fetus
Clinical Trials
Neoplasm Metastasis

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Properties of the amniotic membrane may be applicable in cancer therapy. / Seo, Jae Hong; Kim, Yeul Hong; Kim, Jun Suk.

In: Medical Hypotheses, Vol. 70, No. 4, 05.03.2008, p. 812-814.

Research output: Contribution to journalArticle

@article{26f957c8f57f480cb052312f55196b15,
title = "Properties of the amniotic membrane may be applicable in cancer therapy",
abstract = "The amniotic membrane secretes various substances and has many functions, such as antiangiogenic activity, immunoregulatory activity, pro-apoptotic activity, antimicrobial properties, antifibroblastic activity, cell migration, and cell growth-promoting activity. Of these functions, we mainly focus on antiangiogenic activity, immunoregulatory activity, and pro-apoptotic activity and their applications in tumor biology. The amniotic membrane provides a privileged space anatomically, physiologically, and immunologically to the fetus. Angiogenesis occurs in tumor growth, and destruction of the immunologic barrier is an inevitable process in tumor invasion and metastasis. Regarding tumor cell killing, the pro-apoptotic pathway should be activated. Therefore, if we could apply the characteristics of the amniotic membrane to tumor biology, we might encounter a breakthrough in cancer treatment. For example, if a tumor mass could be enclosed by the amniotic membrane surgically, the growth of the tumor might be retarded. Further experiments and clinical trials should be conducted to verify our hypotheses.",
author = "Seo, {Jae Hong} and Kim, {Yeul Hong} and Kim, {Jun Suk}",
year = "2008",
month = "3",
day = "5",
doi = "10.1016/j.mehy.2007.08.008",
language = "English",
volume = "70",
pages = "812--814",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - Properties of the amniotic membrane may be applicable in cancer therapy

AU - Seo, Jae Hong

AU - Kim, Yeul Hong

AU - Kim, Jun Suk

PY - 2008/3/5

Y1 - 2008/3/5

N2 - The amniotic membrane secretes various substances and has many functions, such as antiangiogenic activity, immunoregulatory activity, pro-apoptotic activity, antimicrobial properties, antifibroblastic activity, cell migration, and cell growth-promoting activity. Of these functions, we mainly focus on antiangiogenic activity, immunoregulatory activity, and pro-apoptotic activity and their applications in tumor biology. The amniotic membrane provides a privileged space anatomically, physiologically, and immunologically to the fetus. Angiogenesis occurs in tumor growth, and destruction of the immunologic barrier is an inevitable process in tumor invasion and metastasis. Regarding tumor cell killing, the pro-apoptotic pathway should be activated. Therefore, if we could apply the characteristics of the amniotic membrane to tumor biology, we might encounter a breakthrough in cancer treatment. For example, if a tumor mass could be enclosed by the amniotic membrane surgically, the growth of the tumor might be retarded. Further experiments and clinical trials should be conducted to verify our hypotheses.

AB - The amniotic membrane secretes various substances and has many functions, such as antiangiogenic activity, immunoregulatory activity, pro-apoptotic activity, antimicrobial properties, antifibroblastic activity, cell migration, and cell growth-promoting activity. Of these functions, we mainly focus on antiangiogenic activity, immunoregulatory activity, and pro-apoptotic activity and their applications in tumor biology. The amniotic membrane provides a privileged space anatomically, physiologically, and immunologically to the fetus. Angiogenesis occurs in tumor growth, and destruction of the immunologic barrier is an inevitable process in tumor invasion and metastasis. Regarding tumor cell killing, the pro-apoptotic pathway should be activated. Therefore, if we could apply the characteristics of the amniotic membrane to tumor biology, we might encounter a breakthrough in cancer treatment. For example, if a tumor mass could be enclosed by the amniotic membrane surgically, the growth of the tumor might be retarded. Further experiments and clinical trials should be conducted to verify our hypotheses.

UR - http://www.scopus.com/inward/record.url?scp=39849107192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39849107192&partnerID=8YFLogxK

U2 - 10.1016/j.mehy.2007.08.008

DO - 10.1016/j.mehy.2007.08.008

M3 - Article

VL - 70

SP - 812

EP - 814

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 4

ER -