Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity

Hyun-Seuk Moon, Hong Gu Lee, Yun Jaie Choi, Tae Gyu Kim, Chong Su Cho

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Green tea catechins (GTCs) are polyphenolic flavonoids formerly called vitamin P. GTCs, especially (-)-epigallocatechin-3-gallate (EGCG), lower the incidence of cancers, collagen-induced arthritis, oxidative stress-induced neurodegenerative diseases, and streptozotocin-induced diabetes. Also, inhibition of adipogenesis by green tea and green tea extract has been demonstrated in cell lines, animal models, and humans. The obesity-preventive effects of green tea and its main constituent EGCG are widely supported by results from epidemiological, cell culture, animal, and clinical studies in the last decade. Studies with adipocyte cell lines and animal models have demonstrated that EGCG inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins, and down-regulates lipogenic enzymes as well as other potential targets. Also, the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity. In addition, it was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus. In this review, the biological activities and multiple mechanisms of EGCG in cell lines, animal models, and clinical observations are explained.

Original languageEnglish
Pages (from-to)85-98
Number of pages14
JournalChemico-Biological Interactions
Volume167
Issue number2
DOIs
Publication statusPublished - 2007 Apr 25
Externally publishedYes

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Keywords

  • (-)-Epigallocatechin-3-gallate
  • Anti-adipogenic mechanism
  • Clinical application

ASJC Scopus subject areas

  • Toxicology

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