TY - JOUR
T1 - Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity
AU - Moon, Hyun Seuk
AU - Lee, Hong Gu
AU - Choi, Yun Jaie
AU - Kim, Tae Gyu
AU - Cho, Chong Su
N1 - Funding Information:
This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We also thank the National Instrumentation Center for Environmental Management (NICEM) for technical assistance. Hyun-Seuk Moon was supported by Brain Korea 21 (BK21) grant.
PY - 2007/4/25
Y1 - 2007/4/25
N2 - Green tea catechins (GTCs) are polyphenolic flavonoids formerly called vitamin P. GTCs, especially (-)-epigallocatechin-3-gallate (EGCG), lower the incidence of cancers, collagen-induced arthritis, oxidative stress-induced neurodegenerative diseases, and streptozotocin-induced diabetes. Also, inhibition of adipogenesis by green tea and green tea extract has been demonstrated in cell lines, animal models, and humans. The obesity-preventive effects of green tea and its main constituent EGCG are widely supported by results from epidemiological, cell culture, animal, and clinical studies in the last decade. Studies with adipocyte cell lines and animal models have demonstrated that EGCG inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins, and down-regulates lipogenic enzymes as well as other potential targets. Also, the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity. In addition, it was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus. In this review, the biological activities and multiple mechanisms of EGCG in cell lines, animal models, and clinical observations are explained.
AB - Green tea catechins (GTCs) are polyphenolic flavonoids formerly called vitamin P. GTCs, especially (-)-epigallocatechin-3-gallate (EGCG), lower the incidence of cancers, collagen-induced arthritis, oxidative stress-induced neurodegenerative diseases, and streptozotocin-induced diabetes. Also, inhibition of adipogenesis by green tea and green tea extract has been demonstrated in cell lines, animal models, and humans. The obesity-preventive effects of green tea and its main constituent EGCG are widely supported by results from epidemiological, cell culture, animal, and clinical studies in the last decade. Studies with adipocyte cell lines and animal models have demonstrated that EGCG inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins, and down-regulates lipogenic enzymes as well as other potential targets. Also, the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity. In addition, it was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus. In this review, the biological activities and multiple mechanisms of EGCG in cell lines, animal models, and clinical observations are explained.
KW - (-)-Epigallocatechin-3-gallate
KW - Anti-adipogenic mechanism
KW - Clinical application
UR - http://www.scopus.com/inward/record.url?scp=33947709927&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2007.02.008
DO - 10.1016/j.cbi.2007.02.008
M3 - Review article
C2 - 17368440
AN - SCOPUS:33947709927
SN - 0009-2797
VL - 167
SP - 85
EP - 98
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 2
ER -
