Prospective partially randomized comparison of clopidogrel loading versus maintenance dosing to prevent periprocedural myocardial infarction after stenting for stable angina pectoris

Jae Hyoung Park, Je Sang Kim, Chul Min Ahn, Soon Jun Hong, Kyung Joo Ahn, Jae Woong Choi, Hyung Joon Joo, Cheol Woong Yu, Do Sun Lim

Research output: Contribution to journalArticlepeer-review

Abstract

What is known and objective: Pre-treatment of clopidogrel 600 mg is better than 300 mg loading for reducing periprocedural myocardial infarction (PMI). We aimed to evaluate pre-treatment methods for preventing PMI among patients undergoing conventional coronary angiography (CAG) for stable angina pectoris. Materials and methods: The study analyzed 402 patients who underwent percutaneous coronary intervention (PCI) during 2010 – 2011 at three Korean hospitals. Clopidogrel-naïve patients received routine maintenance therapy (75 mg/day for ≥ 5 days) and were randomly assigned to a 300-mg reload (RL) or only the maintenance dose (MD). Patients who received a loading dose (LD; 600 mg at 2 – 24 hours before the procedure) were entered into a non-randomized group. Results: After excluding patients who showed an abnormal creatinine kinase myocardial band (CK-MB) level, the study included 233 patients in the LD group, 85 patients in the RL group and 84 patients in the MD group. The LD group had a significantly higher rate of PMI (LD: 21, RL: 3, MD: 0 cases; p = 0.007) and a significant increase in the mean CK-MB levels after 8 hours (p = 0.016) and 24 h (p = 0.01). However, there was no difference in PMI between the RL and MD groups. Furthermore, no significant differences between the three groups were observed in the P2Y12 reaction unit (PRU) values (p = 0.57). Albeit not significantly, the LD group had a higher rate of moderate-to-severe GUSTO bleeding within 7 days. What is new and conclusion: Clopidogrel maintenance is better than 600-mg loading for preventing PMI, and the RL protocol did not further prevent PMI.

Original languageEnglish
Pages (from-to)523-530
Number of pages8
JournalInternational journal of clinical pharmacology and therapeutics
Volume58
Issue number10
DOIs
Publication statusPublished - 2020 Oct

Keywords

  • Angina
  • Clopidogrel
  • Myocardial infarction
  • Stable

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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