Prostaglandin D2 synthase related to estrogen in the female reproductive tract

Whasun Lim, Seung Min Bae, Gahee Jo, Fuller W. Bazer, Youngsok Choi, Gwonhwa Song

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Prostaglandin D2 synthase (PTGDS), also known as a glutathione-independent prostaglandin D synthase, catalyzes prostaglandin H2 to prostaglandin D2 that exhibits functions that include regulation of the central nervous system, contraction/relaxation of smooth muscle and inhibition of platelet aggregation. Gene profiling data based on our previous study indicated that PTGDS is significantly increased during development, differentiation and remodeling of the oviduct in chickens in response to estrogen. Therefore, the aims of the present study were to investigate expression of PTGDS in the oviduct and examine if the relationship between PTGDS and estrogen is conserved during development and remodeling of the oviduct. Results of our study indicate d that PTGDS expression is specifically localized to the luminal (LE) and glandular epithelial (GE) cells of the chicken oviduct in response to diethylstilbestrol, a synthetic estrogen. In addition, PTGDS expression increased during the regeneration phase of the oviduct in concert with increasing concentrations of estrogen in the circulation of laying hens during induced molting. Moreover, PTGDS mRNA and protein were expressed abundantly in GE of ovarian carcinoma, but not in normal ovaries. These results provide the first evidence that PTGDS is a novel estrogen-stimulated gene in oviductal epithelial cells, as well as a candidate biomarker for diagnosis of ovarian carcinoma.

Original languageEnglish
Pages (from-to)355-360
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume456
Issue number1
DOIs
Publication statusPublished - 2015 Jan 2

Fingerprint

prostaglandin R2 D-isomerase
Estrogens
Oviducts
Chickens
Genes
Epithelial Cells
Prostaglandin H2
Estradiol Congeners
Carcinoma
Prostaglandin D2
Molting
Diethylstilbestrol
Neurology
Biomarkers
Platelets
Platelet Aggregation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Prostaglandin D2 synthase related to estrogen in the female reproductive tract. / Lim, Whasun; Bae, Seung Min; Jo, Gahee; Bazer, Fuller W.; Choi, Youngsok; Song, Gwonhwa.

In: Biochemical and Biophysical Research Communications, Vol. 456, No. 1, 02.01.2015, p. 355-360.

Research output: Contribution to journalArticle

Lim, Whasun ; Bae, Seung Min ; Jo, Gahee ; Bazer, Fuller W. ; Choi, Youngsok ; Song, Gwonhwa. / Prostaglandin D2 synthase related to estrogen in the female reproductive tract. In: Biochemical and Biophysical Research Communications. 2015 ; Vol. 456, No. 1. pp. 355-360.
@article{36a737e4c4344d188209a7ae1f583a92,
title = "Prostaglandin D2 synthase related to estrogen in the female reproductive tract",
abstract = "Prostaglandin D2 synthase (PTGDS), also known as a glutathione-independent prostaglandin D synthase, catalyzes prostaglandin H2 to prostaglandin D2 that exhibits functions that include regulation of the central nervous system, contraction/relaxation of smooth muscle and inhibition of platelet aggregation. Gene profiling data based on our previous study indicated that PTGDS is significantly increased during development, differentiation and remodeling of the oviduct in chickens in response to estrogen. Therefore, the aims of the present study were to investigate expression of PTGDS in the oviduct and examine if the relationship between PTGDS and estrogen is conserved during development and remodeling of the oviduct. Results of our study indicate d that PTGDS expression is specifically localized to the luminal (LE) and glandular epithelial (GE) cells of the chicken oviduct in response to diethylstilbestrol, a synthetic estrogen. In addition, PTGDS expression increased during the regeneration phase of the oviduct in concert with increasing concentrations of estrogen in the circulation of laying hens during induced molting. Moreover, PTGDS mRNA and protein were expressed abundantly in GE of ovarian carcinoma, but not in normal ovaries. These results provide the first evidence that PTGDS is a novel estrogen-stimulated gene in oviductal epithelial cells, as well as a candidate biomarker for diagnosis of ovarian carcinoma.",
keywords = "Estrogen, Ovarian cancer, Oviduct, PTGDS",
author = "Whasun Lim and Bae, {Seung Min} and Gahee Jo and Bazer, {Fuller W.} and Youngsok Choi and Gwonhwa Song",
year = "2015",
month = "1",
day = "2",
doi = "10.1016/j.bbrc.2014.11.086",
language = "English",
volume = "456",
pages = "355--360",
journal = "The BMJ",
issn = "0730-6512",
publisher = "Kluwer Academic Publishers",
number = "1",

}

TY - JOUR

T1 - Prostaglandin D2 synthase related to estrogen in the female reproductive tract

AU - Lim, Whasun

AU - Bae, Seung Min

AU - Jo, Gahee

AU - Bazer, Fuller W.

AU - Choi, Youngsok

AU - Song, Gwonhwa

PY - 2015/1/2

Y1 - 2015/1/2

N2 - Prostaglandin D2 synthase (PTGDS), also known as a glutathione-independent prostaglandin D synthase, catalyzes prostaglandin H2 to prostaglandin D2 that exhibits functions that include regulation of the central nervous system, contraction/relaxation of smooth muscle and inhibition of platelet aggregation. Gene profiling data based on our previous study indicated that PTGDS is significantly increased during development, differentiation and remodeling of the oviduct in chickens in response to estrogen. Therefore, the aims of the present study were to investigate expression of PTGDS in the oviduct and examine if the relationship between PTGDS and estrogen is conserved during development and remodeling of the oviduct. Results of our study indicate d that PTGDS expression is specifically localized to the luminal (LE) and glandular epithelial (GE) cells of the chicken oviduct in response to diethylstilbestrol, a synthetic estrogen. In addition, PTGDS expression increased during the regeneration phase of the oviduct in concert with increasing concentrations of estrogen in the circulation of laying hens during induced molting. Moreover, PTGDS mRNA and protein were expressed abundantly in GE of ovarian carcinoma, but not in normal ovaries. These results provide the first evidence that PTGDS is a novel estrogen-stimulated gene in oviductal epithelial cells, as well as a candidate biomarker for diagnosis of ovarian carcinoma.

AB - Prostaglandin D2 synthase (PTGDS), also known as a glutathione-independent prostaglandin D synthase, catalyzes prostaglandin H2 to prostaglandin D2 that exhibits functions that include regulation of the central nervous system, contraction/relaxation of smooth muscle and inhibition of platelet aggregation. Gene profiling data based on our previous study indicated that PTGDS is significantly increased during development, differentiation and remodeling of the oviduct in chickens in response to estrogen. Therefore, the aims of the present study were to investigate expression of PTGDS in the oviduct and examine if the relationship between PTGDS and estrogen is conserved during development and remodeling of the oviduct. Results of our study indicate d that PTGDS expression is specifically localized to the luminal (LE) and glandular epithelial (GE) cells of the chicken oviduct in response to diethylstilbestrol, a synthetic estrogen. In addition, PTGDS expression increased during the regeneration phase of the oviduct in concert with increasing concentrations of estrogen in the circulation of laying hens during induced molting. Moreover, PTGDS mRNA and protein were expressed abundantly in GE of ovarian carcinoma, but not in normal ovaries. These results provide the first evidence that PTGDS is a novel estrogen-stimulated gene in oviductal epithelial cells, as well as a candidate biomarker for diagnosis of ovarian carcinoma.

KW - Estrogen

KW - Ovarian cancer

KW - Oviduct

KW - PTGDS

UR - http://www.scopus.com/inward/record.url?scp=84919691794&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919691794&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2014.11.086

DO - 10.1016/j.bbrc.2014.11.086

M3 - Article

C2 - 25475724

AN - SCOPUS:84919691794

VL - 456

SP - 355

EP - 360

JO - The BMJ

JF - The BMJ

SN - 0730-6512

IS - 1

ER -