Proteasome inhibition promotes functional recovery after peripheral nerve reperfusion injury

Jong Woong Park, Kwang Mo Kim, Kwang Joon Oh, Im Joo Rhyu, Hyon Seok Jang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUNDS: The proteasome degrades NF-κB blocking protein (I-κB) and activates NF-κB that plays as a key transcriptional factor to regulate inflammatory factors that are involved in the tissue reperfusion injury. This study was designed to assess whether the proteasome inhibitor can attenuate peripheral nerve ischemia/reperfusion (I/R) injury and consequently promote motor functional recovery after ischemic insult. METHODS: Rat sciatic nerves were exposed to 2 hour of ischemia followed by various periods of reperfusion. Rats were administered either proteasome inhibitor (bortezomib) or phosphate-buffered saline 30 minutes before reperfusion start. Results were evaluated using a walking track test, and an isolated muscle contraction test, and by muscle weight, and histology. RESULTS: Bortezomib treatment induced an earlier improvement in sciatic functional index and a more rapid restoration of contractile force and wet weight of extensor digitorum longus muscle. Bortezomib reduced early axonal degeneration and promoted regeneration. CONCLUSION: This study indicates that bortezomib; a proteasome inhibitor, is effective at promoting the functional recovery of reperfused peripheral nerve. The proteasome inhibition may play a role as one of the clinical strategy in the peripheral nervous system I/R injury with further understanding its mechanism of action.

Original languageEnglish
Pages (from-to)743-748
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume66
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Peripheral Nerve Injuries
Proteasome Endopeptidase Complex
Reperfusion Injury
Proteasome Inhibitors
Peripheral Nerves
Reperfusion
Weights and Measures
Muscles
Peripheral Nervous System
Sciatic Nerve
Muscle Contraction
Walking
Regeneration
Histology
Ischemia
Phosphates
Bortezomib
Therapeutics

Keywords

  • Nerve
  • Proteasome inhibition
  • Rat
  • Reperfusion

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Proteasome inhibition promotes functional recovery after peripheral nerve reperfusion injury. / Park, Jong Woong; Kim, Kwang Mo; Oh, Kwang Joon; Rhyu, Im Joo; Jang, Hyon Seok.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 66, No. 3, 01.03.2009, p. 743-748.

Research output: Contribution to journalArticle

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