Proteasome inhibition promotes functional recovery after peripheral nerve reperfusion injury

Jong Woong Park, Kwang Mo Kim, Kwang Joon Oh, Im Joo Rhyu, Hyon Seok Jang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUNDS: The proteasome degrades NF-κB blocking protein (I-κB) and activates NF-κB that plays as a key transcriptional factor to regulate inflammatory factors that are involved in the tissue reperfusion injury. This study was designed to assess whether the proteasome inhibitor can attenuate peripheral nerve ischemia/reperfusion (I/R) injury and consequently promote motor functional recovery after ischemic insult. METHODS: Rat sciatic nerves were exposed to 2 hour of ischemia followed by various periods of reperfusion. Rats were administered either proteasome inhibitor (bortezomib) or phosphate-buffered saline 30 minutes before reperfusion start. Results were evaluated using a walking track test, and an isolated muscle contraction test, and by muscle weight, and histology. RESULTS: Bortezomib treatment induced an earlier improvement in sciatic functional index and a more rapid restoration of contractile force and wet weight of extensor digitorum longus muscle. Bortezomib reduced early axonal degeneration and promoted regeneration. CONCLUSION: This study indicates that bortezomib; a proteasome inhibitor, is effective at promoting the functional recovery of reperfused peripheral nerve. The proteasome inhibition may play a role as one of the clinical strategy in the peripheral nervous system I/R injury with further understanding its mechanism of action.

Original languageEnglish
Pages (from-to)743-748
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume66
Issue number3
DOIs
Publication statusPublished - 2009 Mar

Keywords

  • Nerve
  • Proteasome inhibition
  • Rat
  • Reperfusion

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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