TY - JOUR
T1 - Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats
AU - Kim, Jeong Hwan
AU - Kim, Young Sik
AU - Song, Gwan Gyu
AU - Park, Jong Jae
AU - Chang, Hyo Ihl
PY - 2005/5/2
Y1 - 2005/5/2
N2 - Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration in rats. The oral administration of astaxanthin (1, 5, and 25 mg/kg of body weight) showed a significant protection against naproxen (80 mg/kg of body weight)-induced gastric antral ulcer and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment of astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly proved that the acute gastric mucosal lesion induced by naproxen nearly disappeared after the pretreatment of astaxanthin. These results suggest that astaxanthin removes the lipid peroxides and free radicals induced by naproxen, and it may offer potential remedy of gastric ulceration.
AB - Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration in rats. The oral administration of astaxanthin (1, 5, and 25 mg/kg of body weight) showed a significant protection against naproxen (80 mg/kg of body weight)-induced gastric antral ulcer and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment of astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly proved that the acute gastric mucosal lesion induced by naproxen nearly disappeared after the pretreatment of astaxanthin. These results suggest that astaxanthin removes the lipid peroxides and free radicals induced by naproxen, and it may offer potential remedy of gastric ulceration.
KW - Anti-ulcer drug
KW - Astaxanthin
KW - Gastric antral ulceration
KW - Orogastric administration
KW - Xanthophyllomyces dendrorhous
UR - http://www.scopus.com/inward/record.url?scp=18844430871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18844430871&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2005.03.034
DO - 10.1016/j.ejphar.2005.03.034
M3 - Article
C2 - 15878324
AN - SCOPUS:18844430871
VL - 514
SP - 53
EP - 59
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -