Protective effect of chlorogenic acid against Aβ-induced neurotoxicity

Chan Woo Lee, Tae Joon Won, Hak Rim Kim, Dongho Lee, Kwang Woo Hwang, So Young Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Beta-amyloid (Aβ) is considered as one of the major causes of Alzheimer's disease. This study examined the neuroprotective effects of chlorogenic acid, a naturally occurring polyphenol which is distributed widely in plants, fruits and vegetables, against Aβ-induced toxicity. Aβ decreased significantly the viability of PC12 cells. This was accompanied by an increase in the intracellular calcium levels and cleaved caspase-3. In addition, Aβ induced an increase in Bax, and a decrease in Bcl-2 compared to the controls. However, a pre-treatment with chlorogenic acid rescued the PC12 cells from Aβ by attenuating the elevated intracellular calcium levels and reducing the levels of the apoptosis related proteins, including caspase-3, Bcl-2 and Bax. These results suggest that the protective effects of chlorogenic acid are, at least in parts, by attenuating the intracellular calcium influx and reducing apoptosis induced by Aβ.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalBiomolecules and Therapeutics
Volume19
Issue number2
DOIs
Publication statusPublished - 2011 Apr 1

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Keywords

  • Apoptosis
  • Beta-amyloid
  • Calcium influx
  • Chlorogenic acid
  • PC12 cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

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