Protective effect of Korean red ginseng extract on cisplatin ototoxicity in HEI-OC1 auditory cells

Gi Jung Im, Ji Won Chang, June Choi, Sung Won Chae, Eun Ju Ko, Hak Hyun Jung

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Ginseng extract is known to have many beneficial effects, including the reversal of pathological and physiological changes induced by ischemia, stress, and aging. Cisplatin, an effective antineoplastic drug, can cause irreversible sensorineural hearing loss and serious tinnitus in humans; thus cisplatin-induced ototoxicity is a useful experimental model for ototoxicity. This study investigated the protective effects of Korean red ginseng extract on cisplatin-induced ototoxicity in auditory cells. Pretreatment with 2.5 mg/mL of ginseng extract prior to application of 20 μM of cisplatin significantly increased cell viability after 48 h of incubation in auditory cells. Pretreatment with ginseng extract significantly attenuated the cisplatin-induced increase in reactive oxygen species (ROS). Ginseng extract also inhibited the expression of caspase-3 and poly-ADP-ribose polymerase related to cisplatin-induced apoptosis because a major mechanism of cisplatin-induced toxicity involves ROS production. Thus, Korean red ginseng extract can play both an anti-apoptotic and anti-oxidative role on cisplatin-induced ototoxicity in an auditory cell line.

    Original languageEnglish
    Pages (from-to)614-621
    Number of pages8
    JournalPhytotherapy Research
    Volume24
    Issue number4
    DOIs
    Publication statusPublished - 2010 Apr

    Keywords

    • Cisplatin
    • Ginseng
    • Ototoxicity

    ASJC Scopus subject areas

    • Pharmacology

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