Protective effect of linoleic acid against inflammatory reactions by mast cell via caspase-1 cascade pathways

Hee Yun Kim, Sang Ho Rho, Jin Ho Lim, Hyun Jin Park, Hyun Ja Jeong

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Blockade of caspase-1 was reported to be a new target for allergic inflammation treatment. Here, we present the effect of linoleic acid (LA), a constituent of Allium hookeri (AH), to alleviate mast cell-mediated allergic inflammation. Pretreatment of LA and AH significantly reduced caspase-1 activation without displaying host cell cytotoxicity in activated human mast cells. IC50 value of LA on caspase-1 activity is 0.014 μM. LA and AH pretreatment effectively regulated increased levels of interleukin (IL)-1β, IL-6, IL-8, thymic stromal lymphopoietin, and tumor necrosis factor on activated human mast cells. Moreover, LA and AH were effective against activations of nuclear factor-κB and mitogen-activated protein kinases in human mast cells. In summary, LA and AH alleviate allergic inflammatory reactions via blocking caspase-1 cascade signaling pathway. These results provide evidence for the anti-allergic inflammatory properties of LA and AH and corroborate its potential use for the treatment and prevention of allergic diseases. Practical applications: Allium hookeri (AH) is used as traditional food to treat various diseases and contains an essential fatty acid, linoleic acid (LA). LA and AH alleviate mast cell-mediated allergic inflammatory reactions via inhibiting inflammatory mediators. These results provide evidence for the anti-allergic inflammatory properties of LA and AH and corroborate its potential use for the treatment and prevention of allergic diseases.

Original languageEnglish
Article numbere12932
JournalJournal of Food Biochemistry
Volume43
Issue number8
DOIs
Publication statusPublished - 2019

Keywords

  • Allium hookeri
  • caspase-1
  • linoleic acid
  • mast cells
  • nuclear factor-κB
  • thymic stromal lymphopoietin

ASJC Scopus subject areas

  • Food Science
  • Biophysics
  • Pharmacology
  • Cell Biology

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