Protective effect of triphala on radiation induced acute intestinal mucosal damage in sprague dawley rats

Won Sup Yoon, Chul Yong Kim, Dae Sik Yang, Young Je Park, Won Park, Yong Chan Ahn, Seok Hyung Kim, Ghee Young Kwon

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Abstract

Aim of the study was to determine protective effect of triphala on radiation-induced rectal mucosal damage. Male Sprague Dawley rats (30) were divided into 5 groups. Rats in group A were sham irradiated and rats in group B underwent only irradiation. Rats in group C were administered triphala 1g/kg/day orally for 5 consecutive days before irradiation. Rats in group D and E were administered triphala 1 and 1.5 g/kg/day orally for 10 consecutive days, respectively. Rectal mucosal damage was induced by a single fraction of 12.5Gy gamma irradiation (Ir-192) on 5 th day. All the rats were autopsied on 11 th day and histological changes in surface epithelium, glands, and lamina propria were assessed. Proctitis showed significant improvement in surface epithelium (P<0.024), glands (P<0.000) and lamina propria (P<0.002) in group E compared to group B. Rats in group E showed significantly less change in glands (P<0.000) compared to rats in group D, All histological variables (surface epithelium, P<0.001; glands, P<0.000; lamina propria, P<0.003) compared to rats in group C. In a Tukey-b test, group E had a significantly recovered grade for glands (P<0.000) compared to groups B, C and D. Results of the present study showed that high-dose triphala improved radiation-induced damage of glands.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalIndian Journal of Experimental Biology
Volume50
Issue number3
Publication statusPublished - 2012 Mar 1

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Keywords

  • Epithelium
  • Glands
  • Lamina propria
  • Proctitis
  • Radiation protection
  • Triphala

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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