Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome

Jaehun Jung, Sung Jun Ko, Hong Sang Oh, Song Mi Moon, Jin Won Song, Kyungmin Huh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

As there is no effective treatment against hemorrhagic fever with renal syndrome (HFRS), the development of effective vaccine is important. An inactivated hantavirus vaccine (IHV) has been used in Korea, but there has been controversy regarding its effectiveness. We conducted a case-control study to evaluate the vaccine effectiveness (VE) of IHV against HFRS in the Korean military. Unadjusted and adjusted VEs of IHV were 59.1% and 58.9%, respectively. VE was higher in divisions with high incidence of HFRS (unadjusted VE, 71.4%; adjusted VE, 78.7%). Our study demonstrated the moderate effectiveness of IHV in high-risk populations residing in endemic area.

Original languageEnglish
Pages (from-to)1417-1420
Number of pages4
JournalJournal of Infectious Diseases
Volume217
Issue number9
DOIs
Publication statusPublished - 2018 May 1

Keywords

  • Hantavirus
  • Hemorrhagic fever with renal syndrome
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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