Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Eunmi Kim; Dong Won Lee; Hae Chul Park; Dong Hwee Kim

doi:10.1016/j.ymgmr.2021.100783

Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Eunmi Kim, Dong Won Lee, Hae Chul Park, Dong Hwee Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

Original language	English
Article number	100783
Journal	Molecular Genetics and Metabolism Reports
Volume	28
DOIs	https://doi.org/10.1016/j.ymgmr.2021.100783
Publication status	Published - 2021 Sept

Keywords

Alpha-lipoic acid
Diabetes mellitus
Hair cell
Pancreatic β-cell
Zebrafish

ASJC Scopus subject areas

Molecular Biology
Genetics
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ymgmr.2021.100783

Cite this

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title = "Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model",

abstract = "Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.",

keywords = "Alpha-lipoic acid, Diabetes mellitus, Hair cell, Pancreatic β-cell, Zebrafish",

author = "Eunmi Kim and Lee, {Dong Won} and Park, {Hae Chul} and Kim, {Dong Hwee}",

note = "Funding Information: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) ( NRF-2020R1F1A1069106 ). Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = sep,

doi = "10.1016/j.ymgmr.2021.100783",

language = "English",

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journal = "Molecular Genetics and Metabolism Reports",

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AU - Kim, Eunmi

AU - Lee, Dong Won

AU - Park, Hae Chul

AU - Kim, Dong Hwee

PY - 2021/9

Y1 - 2021/9

N2 - Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

AB - Hearing impairment is one of the complications in diabetes mellitus; however, there are very few therapeutic studies on it. In this study, we investigated the protective effect of alpha-lipoic acid (ALA) on hearing loss in diabetic transgenic zebrafish and confirmed that ALA protects the loss of hair cells (HCs) caused by hyperglycemia. The data indicated that ALA has a protective effect on the damage to HCs in diabetic zebrafish.

KW - Alpha-lipoic acid

KW - Diabetes mellitus

KW - Hair cell

KW - Pancreatic β-cell

KW - Zebrafish

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U2 - 10.1016/j.ymgmr.2021.100783

DO - 10.1016/j.ymgmr.2021.100783

M3 - Article

AN - SCOPUS:85110426849

SN - 2214-4269

VL - 28

JO - Molecular Genetics and Metabolism Reports

JF - Molecular Genetics and Metabolism Reports

M1 - 100783

ER -

Protective effects of alpha-lipoic acid on hair cell damage in diabetic zebrafish model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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