Protective effects of kaempferol (3,4′,5,7-tetrahydroxyflavone) against amyloid beta peptide (Aβ)-Induced neurotoxicity in ICR mice

Jae Kyeom Kim, Soo Jung Choi, Hong Yon Cho, Han Joon Hwang, Young Jun Kim, Seung Taik Lim, Chang Ju Kim, Hye Kyung Kim, Sabrina Peterson, Dong Hoon Shin

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52 Citations (Scopus)

Abstract

To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Aβ)- induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number2
DOIs
Publication statusPublished - 2010 Mar 1

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Keywords

  • Alzheimer's disease
  • Amyloid beta peptide
  • Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone)
  • Oxidative stress

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

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